Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3956842..3958562 Replicon chromosome
Accession NZ_CP016638
Organism Burkholderia pseudomallei strain M1

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag A7U58_RS17540 Protein ID WP_059642481.1
Coordinates 3956842..3957486 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag A7U58_RS17545 Protein ID WP_065793620.1
Coordinates 3957486..3958562 (+) Length 359 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U58_RS17535 3952267..3952497 + 231 WP_065793619.1 type I toxin-antitoxin system ptaRNA1 family toxin -
A7U58_RS39280 3952528..3952683 - 156 WP_155122752.1 hypothetical protein -
A7U58_RS39285 3953239..3953853 + 615 WP_129112001.1 hypothetical protein -
A7U58_RS34845 3953853..3954977 + 1125 WP_082250077.1 ImmA/IrrE family metallo-endopeptidase -
A7U58_RS34850 3955007..3955477 + 471 WP_080306021.1 hypothetical protein -
A7U58_RS34855 3955863..3956186 + 324 WP_094188790.1 helix-turn-helix domain-containing protein -
A7U58_RS34860 3956273..3956842 + 570 WP_082250078.1 DUF4433 domain-containing protein -
A7U58_RS17540 3956842..3957486 + 645 WP_059642481.1 DUF4433 domain-containing protein Toxin
A7U58_RS17545 3957486..3958562 + 1077 WP_065793620.1 macro domain-containing protein Antitoxin
A7U58_RS17550 3958929..3959426 + 498 WP_004199888.1 terminase -
A7U58_RS17555 3959423..3960478 + 1056 WP_041192239.1 phage portal protein -
A7U58_RS17560 3960522..3960878 - 357 WP_004202809.1 putative addiction module antidote protein -
A7U58_RS17565 3960881..3961177 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin -
A7U58_RS34865 3961845..3963101 + 1257 WP_004552667.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3942954..3968466 25512


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 24887.60 Da        Isoelectric Point: 7.5391

>T64946 WP_059642481.1 NZ_CP016638:3956842-3957486 [Burkholderia pseudomallei]
MLYTSLNPEKALIWRIVHRDNLPWILDNGLYCGNSAVKAPAWVNIGNPELIDKRAHHPVPLPPRGLLNDYVPFYFTPFSP
MLRNIHTGWGGIQKRPNEEIVILVSSLHHIAGLGLPFLFTDSHAYYRWADYYSDLAYLDKIDWPLLQRRDFKRDPDDPAK
FERYQAEALIHQHLPVGGLLGIVCYTEPLKQRIEQEIQARNLNLPVYARTGWYF

Download         Length: 645 bp

>T64946 NZ_CP016638:3956842-3957486 [Burkholderia pseudomallei]
ATGCTCTATACCAGCCTTAATCCGGAAAAAGCACTGATCTGGCGGATTGTCCACCGCGACAATCTGCCGTGGATTCTGGA
CAATGGCCTGTATTGCGGCAACAGCGCGGTGAAGGCGCCGGCATGGGTGAATATCGGTAACCCGGAGCTTATCGACAAGC
GCGCCCATCACCCGGTGCCGTTGCCGCCGCGCGGCTTGCTGAATGACTATGTACCGTTCTATTTCACGCCCTTCTCGCCG
ATGCTGCGTAACATTCACACCGGATGGGGCGGAATCCAGAAGCGGCCGAATGAAGAAATCGTGATCTTGGTGTCTAGCCT
GCACCACATTGCAGGGTTGGGCTTGCCGTTTTTGTTTACTGACAGTCATGCCTATTATCGTTGGGCAGATTACTACTCGG
ACTTGGCCTACCTCGATAAGATCGACTGGCCTTTGCTACAGCGAAGGGATTTCAAGCGTGACCCGGACGACCCCGCCAAG
TTCGAGCGCTATCAGGCGGAGGCGCTGATTCACCAACACTTGCCAGTGGGCGGACTTCTCGGCATCGTGTGCTATACGGA
ACCTTTGAAACAACGCATCGAACAGGAGATTCAGGCCCGTAATCTGAACCTGCCGGTTTATGCCCGAACAGGGTGGTACT
TCTGA

Antitoxin


Download         Length: 359 a.a.        Molecular weight: 40560.52 Da        Isoelectric Point: 6.0092

>AT64946 WP_065793620.1 NZ_CP016638:3957486-3958562 [Burkholderia pseudomallei]
MITFTQGNLLEARTEALVNTVNTVGVMGKGIALMFKERFDENFRRYAAACKAKEVQTGKMFVTPVHELDGPRWIVNFPTK
QHWRAPSRMEWVVEGLQDLRRFLIEQQVQSIAIPPLGAGNGGLEWADVREQIELALGDLDIDIVVFEPTKQYQNVAKRAG
VEKLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERAIERFNPGENPLNLQFAPHKYGPYANRLDHLLNNLDGSYLH
SEKRIGDANPLDVIWFDDERKAFVQTYLKSEAKAYTQALEFTAALIDGFESPFGMELLATVDWLLTREGVAPNVPALREG
LRHWRGGSDAATRKDRLFDDRALGIALERLTQPATALV

Download         Length: 1077 bp

>AT64946 NZ_CP016638:3957486-3958562 [Burkholderia pseudomallei]
ATGATTACATTCACTCAAGGCAATTTGTTGGAGGCCCGCACTGAGGCGCTGGTCAACACCGTCAACACCGTCGGGGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAACGCTTTGATGAGAACTTCCGCCGCTATGCCGCCGCCTGCAAAGCGAAGG
AAGTGCAGACAGGCAAGATGTTTGTGACGCCGGTGCACGAACTCGATGGGCCGCGCTGGATCGTTAATTTCCCTACCAAG
CAGCACTGGCGTGCGCCCTCGCGCATGGAGTGGGTGGTGGAAGGCTTGCAGGACCTGCGGCGCTTCTTGATCGAGCAACA
GGTTCAATCCATCGCTATCCCGCCGCTGGGTGCGGGTAACGGTGGCCTGGAATGGGCTGATGTGCGTGAGCAGATCGAAC
TGGCGTTGGGCGATCTGGACATCGACATTGTGGTGTTCGAGCCCACCAAGCAATACCAGAACGTGGCCAAGCGTGCTGGC
GTAGAAAAGCTGACGCCCGCCCGAGCGCTGATCGCCGAATTGGTGCGCCGGTACTGGGTGCTGGGCATGGAATGCAGCTT
GCTGGAGATCCAGAAGCTGGCGTGGTTTCTGGAACGCGCCATTGAGCGTTTCAACCCAGGTGAAAACCCGCTGAACTTGC
AGTTTGCACCACACAAATACGGTCCCTACGCCAACCGACTTGACCACCTGTTGAACAATCTGGATGGCAGCTACCTGCAC
TCTGAAAAGCGCATCGGCGATGCCAATCCGCTGGACGTGATTTGGTTCGACGACGAACGCAAGGCTTTTGTTCAGACATA
TCTCAAGAGCGAAGCCAAGGCCTACACGCAAGCTCTTGAATTCACGGCGGCACTGATCGATGGCTTTGAATCACCCTTTG
GCATGGAACTGCTGGCGACCGTGGATTGGTTGCTGACCCGTGAAGGCGTGGCACCCAACGTGCCGGCCTTGCGCGAAGGG
CTCCGTCATTGGCGCGGTGGTTCAGATGCTGCCACCCGTAAGGACCGCCTTTTTGATGATCGGGCACTGGGCATCGCCCT
GGAGCGTCTGACACAGCCTGCGACAGCGCTGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References