Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 894791..895427 Replicon chromosome
Accession NZ_CP016622
Organism Parageobacillus thermoglucosidasius strain Wild Type

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag BCV53_RS04425 Protein ID WP_003253417.1
Coordinates 895077..895427 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A178U3Z0
Locus tag BCV53_RS04420 Protein ID WP_003253419.1
Coordinates 894791..895072 (+) Length 94 a.a.

Genomic Context

BCV53_RS04405BCV53_RS04410BCV53_RS04415BCV53_RS04420BCV53_RS04425BCV53_RS04430BCV53_RS04435BCV53_RS04400BCV53_RS20565
Location: 891880..892242 (363 bp)
Type: Others
Protein ID: WP_013877619.1
Location: 892324..893337 (1014 bp)
Type: Others
Protein ID: WP_042385737.1
Location: 893514..894668 (1155 bp)
Type: Others
Protein ID: WP_003253421.1
Location: 894791..895072 (282 bp)
Type: Antitoxin
Protein ID: WP_003253419.1
Location: 895077..895427 (351 bp)
Type: Toxin
Protein ID: WP_003253417.1
Location: 895638..897824 (2187 bp)
Type: Others
Protein ID: WP_003253404.1
Location: 898020..898487 (468 bp)
Type: Others
Protein ID: WP_003253403.1
Location: 891203..891817 (615 bp)
Type: Others
Protein ID: WP_013401779.1
Location: 897819..897932 (114 bp)
Type: Others
Protein ID: WP_013401775.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BCV53_RS04400891203..891817-615WP_013401779.1rhomboid family intramembrane serine protease-
BCV53_RS04405891880..892242+363WP_013877619.1holo-ACP synthase-
BCV53_RS04410892324..893337+1014WP_042385737.1outer membrane lipoprotein-sorting protein-
BCV53_RS04415893514..894668+1155WP_003253421.1alanine racemase-
BCV53_RS04420894791..895072+282WP_003253419.1hypothetical proteinAntitoxin
BCV53_RS04425895077..895427+351WP_003253417.1type II toxin-antitoxin system endoribonuclease NdoAToxin
BCV53_RS04430895638..897824+2187WP_003253404.1RNA-binding transcriptional accessory protein-
BCV53_RS20565897819..897932-114WP_013401775.1cortex morphogenetic protein CmpA-
BCV53_RS04435898020..898487+468WP_003253403.1SprT family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T64866 WP_003253417.1 NZ_CP016622:895077-895427 [Parageobacillus thermoglucosidasius]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T64866 NZ_CP016622:895077-895427 [Parageobacillus thermoglucosidasius]
TTGATTGTTAAGCGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCGGAACAAGGAGGCGTTCGTCCGGT
ATTAGTCATTCAAAATGACATTGGAAATCGGTTTAGTCCGACGGTGATTGTGGCGGCGATAACAGCGCAAATCCAAAAAG
CAAAGCTGCCGACACATGTTGAAATTGACGCGAAGCGTTACGGGTTTGAGCGGGATTCTGTTATTCTGCTAGAGCAAATT
CGGACGATTGATAAGCAGCGGCTGACAGACAAAATTACTCACTTGGACGATGAAATGATGGATAAGGTGGATGAAGCGCT
GCAAATTAGTTTAGGACTCATAGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 7.0142

>AT64866 WP_003253419.1 NZ_CP016622:894791-895072 [Parageobacillus thermoglucosidasius]
VSESSATTEIVVRLPQALVTELDVLVKQENGNRNDLIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT64866 NZ_CP016622:894791-895072 [Parageobacillus thermoglucosidasius]
GTGTCGGAATCTAGCGCAACAACGGAAATCGTCGTTCGTTTACCTCAAGCACTAGTAACGGAATTGGATGTGCTTGTTAA
ACAAGAGAACGGCAACCGTAATGATCTCATTTATCAAGCAACTAAAATGTACATTCGCGAGCGAAAAAAACGGCAAATCC
GCGAGGCGATGAGACGCGGTTATATGGAAATGGCGAAAATCAATTTATCCATTGCTTCAGAGGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAGCGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9ERQ4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A178U3Z0

References