Detailed information of TA system TA064863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2460654..2461216
• Replicon: chromosome
• Accession: NZ_CP016616
• Organism: Microvirga ossetica strain V5/3m

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BB934_RS11520
• Protein ID: WP_099509757.1
• Coordinates: 2460848..2461216 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BB934_RS11515
• Protein ID: WP_099509756.1
• Coordinates: 2460654..2460851 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB934_RS11500	2456241..2457938	-	1698	WP_099509754.1	30S ribosomal protein S1	-
BB934_RS11505	2458237..2458865	-	629	Protein_2230	2-hydroxychromene-2-carboxylate isomerase	-
BB934_RS11510	2459104..2460336	+	1233	WP_099509755.1	argininosuccinate synthase	-
BB934_RS11515	2460654..2460851	+	198	WP_099509756.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BB934_RS11520	2460848..2461216	+	369	WP_099509757.1	type II toxin-antitoxin system VapC family toxin	Toxin
BB934_RS11525	2461399..2462256	+	858	WP_099509758.1	GNAT family N-acetyltransferase	-
BB934_RS11530	2463620..2465446	+	1827	WP_099509759.1	translational GTPase TypA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13370.44 Da
• Isoelectric Point: 5.5461

>T64863 WP_099509757.1 NZ_CP016616:2460848-2461216 [Microvirga ossetica]
MILVDTSVWIDHLKTGDDNLARLLEAGRVLMHPFVLGELALGSLRNRQTILELLGQLPRAEMATDQEVLSLIEAETLHGT
GIGLIDAHLLASAKLTAGSSLWTRDKRLERLAARLHGSTELE

Nucleotide

• Length: 369 bp

>T64863 NZ_CP016616:2460848-2461216 [Microvirga ossetica]
ATGATCCTGGTCGACACCTCCGTCTGGATCGATCATCTCAAAACGGGCGACGACAACTTGGCCCGCCTCCTGGAAGCCGG
CCGCGTCCTCATGCATCCTTTCGTGCTGGGCGAGCTTGCACTCGGCAGCCTCCGGAACCGACAAACCATTCTTGAACTGC
TCGGACAATTGCCTCGGGCGGAAATGGCAACGGACCAGGAAGTCTTGAGTCTCATCGAAGCGGAAACCCTCCATGGCACC
GGCATCGGCCTCATCGATGCCCATCTTCTCGCTTCGGCGAAGCTGACGGCGGGATCATCCCTGTGGACCCGCGATAAAAG
GCTCGAGCGTCTGGCCGCACGACTGCACGGGTCCACGGAGCTTGAATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7136.27 Da
• Isoelectric Point: 10.9487

>AT64863 WP_099509756.1 NZ_CP016616:2460654-2460851 [Microvirga ossetica]
MRTTIALDDSLVAKAQAMTGLREKSALVREALEALIQRESARRLAKLGGSEPDLRPIPRRQPDPA

Nucleotide

• Length: 198 bp

>AT64863 NZ_CP016616:2460654-2460851 [Microvirga ossetica]
ATGCGCACGACCATTGCCCTGGATGACAGTCTTGTTGCGAAGGCGCAGGCGATGACGGGTCTGCGCGAGAAATCCGCCCT
GGTTCGAGAGGCTTTGGAAGCCTTGATTCAGCGTGAAAGCGCGCGGCGCCTCGCCAAGCTCGGCGGCAGCGAGCCGGATC
TGCGACCCATCCCGCGGCGGCAGCCCGATCCCGCATGA