Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1168520..1169061 Replicon chromosome
Accession NZ_CP016610
Organism Xylella fastidiosa strain Salento-2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BC375_RS05655 Protein ID WP_031336866.1
Coordinates 1168738..1169061 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BC375_RS05650 Protein ID WP_046419240.1
Coordinates 1168520..1168741 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BC375_RS05600 (BC375_05230) 1164739..1164963 - 225 WP_230950005.1 major capsid protein -
BC375_RS05605 (BC375_05235) 1164972..1165178 - 207 WP_046419249.1 hypothetical protein -
BC375_RS05620 (BC375_05240) 1165744..1166331 - 588 WP_046419247.1 hypothetical protein -
BC375_RS05630 (BC375_05245) 1166918..1167100 - 183 WP_046419245.1 hypothetical protein -
BC375_RS05635 1167104..1167370 - 267 WP_080939575.1 hypothetical protein -
BC375_RS05640 (BC375_05250) 1167383..1167658 - 276 WP_230950007.1 hypothetical protein -
BC375_RS05645 (BC375_05255) 1167804..1168232 + 429 WP_046419243.1 DUF3693 domain-containing protein -
BC375_RS05650 (BC375_05260) 1168520..1168741 + 222 WP_046419240.1 antitoxin MazE family protein Antitoxin
BC375_RS05655 (BC375_05265) 1168738..1169061 + 324 WP_031336866.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BC375_RS12320 1169151..1169312 - 162 WP_010894327.1 hypothetical protein -
BC375_RS05660 (BC375_05270) 1169319..1169651 - 333 WP_046419237.1 hypothetical protein -
BC375_RS05665 (BC375_05275) 1169638..1170819 - 1182 WP_046419234.1 replication initiation factor domain-containing protein -
BC375_RS05680 (BC375_05285) 1171428..1172120 - 693 WP_023906504.1 7-cyano-7-deazaguanine synthase QueC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1130275..1174631 44356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11771.81 Da        Isoelectric Point: 7.9848

>T64852 WP_031336866.1 NZ_CP016610:1168738-1169061 [Xylella fastidiosa]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVALCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII

Download         Length: 324 bp

>T64852 NZ_CP016610:1168738-1169061 [Xylella fastidiosa]
ATGATTCAACGTGGCGACCTTGTAACAGTTTCCCTACAAGGCGACTACGGCAAGCCTAGACCAGCGTTGATCGTTCAATC
AGACCTTCTAACGGAGTTAGATAGTGTCGCACTGTGTCCGGTCACGAGCGACCTGCGGAATGCGATATTTCGTGTCACCG
TTGAACCAACCGCGGCCAATGGTTTACGGACACTGTCGCAGGTCATGGTAGATAAAATTTCAACACTACCACGTAACAAA
ATCAGCGAACCTTTTGGACGTCTCAATGACGAGAGAATGAAAGCAATAGAAAGAGCATTGTTACTAATTATTGGTATCAT
TTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8455.64 Da        Isoelectric Point: 9.3510

>AT64852 WP_046419240.1 NZ_CP016610:1168520-1168741 [Xylella fastidiosa]
MTSTHRPDSKIVHHREQMRAAGLRPMQLWVPDTRRPEFAAEIQSQCRALKGDQAEADALRFTEKAMTHIEGWK

Download         Length: 222 bp

>AT64852 NZ_CP016610:1168520-1168741 [Xylella fastidiosa]
ATGACATCAACTCACAGACCAGACAGCAAGATAGTTCACCATAGGGAACAGATGCGCGCAGCGGGATTGCGTCCTATGCA
GCTCTGGGTGCCGGATACGCGCAGACCGGAATTCGCTGCTGAAATTCAAAGCCAGTGCCGCGCCCTGAAAGGCGACCAGG
CAGAAGCCGACGCTTTACGCTTCACAGAAAAAGCCATGACCCATATTGAAGGTTGGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References