Detailed information of TA system TA064851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 982723..983224
• Replicon: chromosome
• Accession: NZ_CP016610
• Organism: Xylella fastidiosa strain Salento-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BC375_RS04545
• Protein ID: WP_046420237.1
• Coordinates: 982928..983224 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: BC375_RS04540
• Protein ID: WP_230950355.1
• Coordinates: 982723..982935 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BC375_RS04500 (BC375_04235)	978663..978923	+	261	WP_023906425.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
BC375_RS04505	978910..979191	+	282	WP_060872372.1	type II toxin-antitoxin system YafQ family toxin	-
BC375_RS04515 (BC375_04250)	979609..980643	-	1035	WP_023906427.1	trypsin-like peptidase domain-containing protein	-
BC375_RS04525 (BC375_04260)	981426..981704	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
BC375_RS04530 (BC375_04265)	981692..981988	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BC375_RS04535	982237..982377	-	141	WP_196488983.1	stabilization protein	-
BC375_RS04540 (BC375_04275)	982723..982935	+	213	WP_230950355.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BC375_RS04545 (BC375_04280)	982928..983224	+	297	WP_046420237.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BC375_RS12740 (BC375_04285)	983686..983949	+	264	WP_023906433.1	hypothetical protein	-
BC375_RS12745	984031..984120	+	90	WP_228762876.1	hypothetical protein	-
BC375_RS04555 (BC375_04290)	984529..984984	+	456	WP_046420235.1	hypothetical protein	-
BC375_RS04560 (BC375_04295)	984981..985253	+	273	WP_046420232.1	hypothetical protein	-
BC375_RS04565 (BC375_04300)	985257..985565	+	309	WP_010894519.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BC375_RS04570 (BC375_04305)	985674..986198	+	525	WP_046420230.1	hypothetical protein	-
BC375_RS04575 (BC375_04310)	986192..986749	+	558	WP_046420226.1	recombinase family protein	-
BC375_RS04580	986779..986988	-	210	WP_060872356.1	hypothetical protein	-
BC375_RS04585 (BC375_04315)	987005..988156	-	1152	Protein_848	toprim domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	986192..986749	557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (9-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11418.96 Da
• Isoelectric Point: 6.8587

>T64851 WP_046420237.1 NZ_CP016610:982928-983224 [Xylella fastidiosa]
MAKSYRLTPLAEADLEEIWFYTFRHWSIGQADSYHRSLVAVFEGLAAGTKQGRPSVLPDFNKYLCGSCGSHVVYFMDYPD
HLDVIRILRQRQDTERYL

Nucleotide

• Length: 297 bp

>T64851 NZ_CP016610:982928-983224 [Xylella fastidiosa]
ATGGCTAAGTCCTATCGACTGACGCCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGGGCAAGCCGACAGCTACCACCGCAGCCTAGTTGCGGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCCGCC
CTTCTGTTCTGCCGGACTTCAATAAATACCTATGTGGTTCATGTGGTTCGCATGTAGTGTATTTCATGGATTACCCCGAT
CACTTGGATGTTATCCGCATTCTGCGCCAGCGGCAGGATACCGAGCGGTACCTATAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7557.38 Da
• Isoelectric Point: 6.8775

>AT64851 WP_230950355.1 NZ_CP016610:982723-982935 [Xylella fastidiosa]
MPSGSTSPAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Nucleotide

• Length: 213 bp

>AT64851 NZ_CP016610:982723-982935 [Xylella fastidiosa]
TTGCCCTCGGGCAGCACTTCGCCAGCCCAAGTCCAGGGCGGTCGCTACGGTACCGCCAGCGATGTTGTCAGGGCCGGTCT
GCGGCTGCTGGAGGAACACGAAACAAAGGTGAAGGCGCTGCAAGATGCGCTGAATGTTGGCCACCAATCCGGCGAGCCGC
GCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGCTAA