Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 981426..981988 | Replicon | chromosome |
| Accession | NZ_CP016610 | ||
| Organism | Xylella fastidiosa strain Salento-2 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9PBR6 |
| Locus tag | BC375_RS04530 | Protein ID | WP_010894527.1 |
| Coordinates | 981692..981988 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9PBR5 |
| Locus tag | BC375_RS04525 | Protein ID | WP_010894528.1 |
| Coordinates | 981426..981704 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BC375_RS04495 (BC375_04230) | 977526..978332 | + | 807 | WP_046420245.1 | oxidoreductase | - |
| BC375_RS04500 (BC375_04235) | 978663..978923 | + | 261 | WP_023906425.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| BC375_RS04505 | 978910..979191 | + | 282 | WP_060872372.1 | type II toxin-antitoxin system YafQ family toxin | - |
| BC375_RS04515 (BC375_04250) | 979609..980643 | - | 1035 | WP_023906427.1 | trypsin-like peptidase domain-containing protein | - |
| BC375_RS04525 (BC375_04260) | 981426..981704 | + | 279 | WP_010894528.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| BC375_RS04530 (BC375_04265) | 981692..981988 | + | 297 | WP_010894527.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BC375_RS04535 | 982237..982377 | - | 141 | WP_196488983.1 | stabilization protein | - |
| BC375_RS04540 (BC375_04275) | 982723..982935 | + | 213 | WP_230950355.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| BC375_RS04545 (BC375_04280) | 982928..983224 | + | 297 | WP_046420237.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BC375_RS12740 (BC375_04285) | 983686..983949 | + | 264 | WP_023906433.1 | hypothetical protein | - |
| BC375_RS12745 | 984031..984120 | + | 90 | WP_228762876.1 | hypothetical protein | - |
| BC375_RS04555 (BC375_04290) | 984529..984984 | + | 456 | WP_046420235.1 | hypothetical protein | - |
| BC375_RS04560 (BC375_04295) | 984981..985253 | + | 273 | WP_046420232.1 | hypothetical protein | - |
| BC375_RS04565 (BC375_04300) | 985257..985565 | + | 309 | WP_010894519.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BC375_RS04570 (BC375_04305) | 985674..986198 | + | 525 | WP_046420230.1 | hypothetical protein | - |
| BC375_RS04575 (BC375_04310) | 986192..986749 | + | 558 | WP_046420226.1 | recombinase family protein | - |
| BC375_RS04580 | 986779..986988 | - | 210 | WP_060872356.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 986192..986749 | 557 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11155.72 Da Isoelectric Point: 7.4670
>T64850 WP_010894527.1 NZ_CP016610:981692-981988 [Xylella fastidiosa]
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS
Download Length: 297 bp
>T64850 NZ_CP016610:981692-981988 [Xylella fastidiosa]
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10772.08 Da Isoelectric Point: 5.6126
>AT64850 WP_010894528.1 NZ_CP016610:981426-981704 [Xylella fastidiosa]
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG
Download Length: 279 bp
>AT64850 NZ_CP016610:981426-981704 [Xylella fastidiosa]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1S0VAK4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1S0V821 |