Detailed information of TA system TA064849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 978663..979191
• Replicon: chromosome
• Accession: NZ_CP016610
• Organism: Xylella fastidiosa strain Salento-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BC375_RS04505
• Protein ID: WP_060872372.1
• Coordinates: 978910..979191 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A1S0V873
• Locus tag: BC375_RS04500
• Protein ID: WP_023906425.1
• Coordinates: 978663..978923 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BC375_RS04490 (BC375_04225)	974418..977480	+	3063	WP_046420247.1	efflux RND transporter permease subunit	-
BC375_RS04495 (BC375_04230)	977526..978332	+	807	WP_046420245.1	oxidoreductase	-
BC375_RS04500 (BC375_04235)	978663..978923	+	261	WP_023906425.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BC375_RS04505	978910..979191	+	282	WP_060872372.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BC375_RS04515 (BC375_04250)	979609..980643	-	1035	WP_023906427.1	trypsin-like peptidase domain-containing protein	-
BC375_RS04525 (BC375_04260)	981426..981704	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
BC375_RS04530 (BC375_04265)	981692..981988	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BC375_RS04535	982237..982377	-	141	WP_196488983.1	stabilization protein	-
BC375_RS04540 (BC375_04275)	982723..982935	+	213	WP_230950355.1	type II toxin-antitoxin system ParD family antitoxin	-
BC375_RS04545 (BC375_04280)	982928..983224	+	297	WP_046420237.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BC375_RS12740 (BC375_04285)	983686..983949	+	264	WP_023906433.1	hypothetical protein	-
BC375_RS12745	984031..984120	+	90	WP_228762876.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10713.46 Da
• Isoelectric Point: 9.0869

>T64849 WP_060872372.1 NZ_CP016610:978910-979191 [Xylella fastidiosa]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALVGNWKDLRDCHIKLDLVLIYTRVDSKTL
TLVRLGSHAELGL

Nucleotide

• Length: 282 bp

>T64849 NZ_CP016610:978910-979191 [Xylella fastidiosa]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAAGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGGTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCTCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGGAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8983.55 Da
• Isoelectric Point: 10.5972

>AT64849 WP_023906425.1 NZ_CP016610:978663-978923 [Xylella fastidiosa]
MAANQLVQARIDGAIKAEATVVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT64849 NZ_CP016610:978663-978923 [Xylella fastidiosa]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCGTTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V873