Detailed information of TA system TA064840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 978588..979116
• Replicon: chromosome
• Accession: NZ_CP016608
• Organism: Xylella fastidiosa strain Salento-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BCV75_RS04495
• Protein ID: WP_060872372.1
• Coordinates: 978835..979116 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A1S0V873
• Locus tag: BCV75_RS04490
• Protein ID: WP_023906425.1
• Coordinates: 978588..978848 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCV75_RS04480 (BCV75_04185)	974343..977405	+	3063	WP_046420247.1	efflux RND transporter permease subunit	-
BCV75_RS04485 (BCV75_04190)	977451..978257	+	807	WP_046420245.1	oxidoreductase	-
BCV75_RS04490 (BCV75_04195)	978588..978848	+	261	WP_023906425.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BCV75_RS04495 (BCV75_04200)	978835..979116	+	282	WP_060872372.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BCV75_RS04505 (BCV75_04205)	979534..980568	-	1035	WP_023906427.1	trypsin-like peptidase domain-containing protein	-
BCV75_RS04515 (BCV75_04215)	981351..981629	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
BCV75_RS04520 (BCV75_04220)	981617..981913	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BCV75_RS04530 (BCV75_04230)	982648..982860	+	213	WP_230950355.1	type II toxin-antitoxin system ParD family antitoxin	-
BCV75_RS04535 (BCV75_04235)	982853..983149	+	297	WP_046420237.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BCV75_RS12715 (BCV75_04240)	983610..983873	+	264	WP_023906433.1	hypothetical protein	-
BCV75_RS12720	983955..984044	+	90	WP_228762876.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10713.46 Da
• Isoelectric Point: 9.0869

>T64840 WP_060872372.1 NZ_CP016608:978835-979116 [Xylella fastidiosa]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALVGNWKDLRDCHIKLDLVLIYTRVDSKTL
TLVRLGSHAELGL

Nucleotide

• Length: 282 bp

>T64840 NZ_CP016608:978835-979116 [Xylella fastidiosa]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAAGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGGTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCTCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGGAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8983.55 Da
• Isoelectric Point: 10.5972

>AT64840 WP_023906425.1 NZ_CP016608:978588-978848 [Xylella fastidiosa]
MAANQLVQARIDGAIKAEATVVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT64840 NZ_CP016608:978588-978848 [Xylella fastidiosa]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCGTTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V873