Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2326990..2327623 Replicon chromosome
Accession NZ_CP016606
Organism Mannheimia granulomatis strain BJ1680.3

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag A6B39_RS11240 Protein ID WP_176671084.1
Coordinates 2327219..2327623 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag A6B39_RS11235 Protein ID WP_176671083.1
Coordinates 2326990..2327235 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6B39_RS11205 2323173..2323586 + 414 WP_176671081.1 preprotein translocase subunit SecE -
A6B39_RS11210 2323588..2324151 + 564 WP_027073310.1 transcription termination/antitermination protein NusG -
A6B39_RS11215 2324376..2324804 + 429 WP_006248758.1 50S ribosomal protein L11 -
A6B39_RS11220 2324809..2325498 + 690 WP_042801713.1 50S ribosomal protein L1 -
A6B39_RS11225 2325783..2326274 + 492 WP_025235143.1 50S ribosomal protein L10 -
A6B39_RS11230 2326330..2326695 + 366 WP_176671082.1 50S ribosomal protein L7/L12 -
A6B39_RS11235 2326990..2327235 + 246 WP_176671083.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A6B39_RS11240 2327219..2327623 + 405 WP_176671084.1 type II toxin-antitoxin system VapC family toxin Toxin
A6B39_RS11245 2327797..2328057 - 261 WP_176671085.1 helix-turn-helix domain-containing protein -
A6B39_RS11250 2328282..2329040 + 759 WP_176671086.1 hypothetical protein -
A6B39_RS11255 2329041..2329232 + 192 WP_176671087.1 hypothetical protein -
A6B39_RS11260 2329261..2330199 + 939 WP_176671088.1 hypothetical protein -
A6B39_RS11265 2330251..2330757 + 507 WP_176671089.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15226.76 Da        Isoelectric Point: 7.6656

>T64838 WP_176671084.1 NZ_CP016606:2327219-2327623 [Mannheimia granulomatis]
MIYMLDTNILIYLMKNRPLAVAERVAQLTPSDQLIMSFVTYAELLKGANGSANPEKALANIDKLKQRISIVYPNEKICEF
YGVWANKLKQQGKPIGGNDLWIACHALACNAILVTHNVKEFERIETLNWQDWTC

Download         Length: 405 bp

>T64838 NZ_CP016606:2327219-2327623 [Mannheimia granulomatis]
ATGATCTATATGCTTGATACTAATATTTTGATTTATTTAATGAAAAATCGACCGCTTGCAGTGGCAGAACGTGTGGCACA
ACTTACGCCAAGTGATCAATTAATTATGAGCTTTGTTACCTATGCTGAATTGCTCAAAGGAGCAAATGGCAGTGCTAATC
CGGAAAAAGCCTTAGCGAATATCGACAAGTTGAAACAACGTATTTCGATTGTTTACCCAAATGAAAAAATCTGTGAATTT
TATGGTGTTTGGGCAAATAAACTGAAGCAACAAGGCAAACCGATTGGCGGAAATGATTTATGGATTGCTTGTCACGCTTT
GGCTTGTAATGCGATATTAGTGACACATAATGTCAAAGAGTTCGAGCGAATTGAAACATTAAATTGGCAAGATTGGACGT
GTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9342.35 Da        Isoelectric Point: 3.9281

>AT64838 WP_176671083.1 NZ_CP016606:2326990-2327235 [Mannheimia granulomatis]
MRTKVFQSGNSQAVRIPFDFRFDVDTVEILQGQNGDVILRPVKPQADMEFLALFSDFDDDFIQALEDRDTSPPQERDDLY
A

Download         Length: 246 bp

>AT64838 NZ_CP016606:2326990-2327235 [Mannheimia granulomatis]
ATGCGAACAAAAGTTTTCCAAAGTGGTAATAGTCAAGCGGTAAGAATTCCGTTTGATTTCCGTTTTGACGTAGATACCGT
AGAGATTTTACAAGGGCAGAATGGCGATGTTATTTTGCGTCCTGTTAAACCTCAAGCCGATATGGAATTTCTGGCTTTAT
TTTCCGATTTTGATGATGATTTTATTCAGGCATTGGAAGATCGAGATACATCGCCACCACAAGAGCGAGATGATCTATAT
GCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References