Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1851385..1851907 Replicon chromosome
Accession NZ_CP016606
Organism Mannheimia granulomatis strain BJ1680.3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag A6B39_RS08855 Protein ID WP_176670574.1
Coordinates 1851385..1851654 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag A6B39_RS08860 Protein ID WP_176670575.1
Coordinates 1851641..1851907 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6B39_RS08835 1846735..1847169 - 435 WP_176670570.1 D-tyrosyl-tRNA(Tyr) deacylase -
A6B39_RS08840 1847144..1847986 - 843 WP_176670571.1 virulence factor BrkB family protein -
A6B39_RS08845 1847988..1849226 - 1239 WP_176670572.1 glutamate-5-semialdehyde dehydrogenase -
A6B39_RS08850 1849446..1851359 + 1914 WP_176670573.1 DNA mismatch repair endonuclease MutL -
A6B39_RS08855 1851385..1851654 - 270 WP_176670574.1 type II toxin-antitoxin system YafQ family toxin Toxin
A6B39_RS08860 1851641..1851907 - 267 WP_176670575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6B39_RS08865 1852066..1853019 + 954 WP_176670576.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
A6B39_RS08870 1853092..1853367 + 276 WP_027073572.1 RNA chaperone Hfq -
A6B39_RS08875 1853387..1854772 + 1386 WP_176670577.1 GTPase HflX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10426.99 Da        Isoelectric Point: 6.2170

>T64837 WP_176670574.1 NZ_CP016606:c1851654-1851385 [Mannheimia granulomatis]
MREIEYSNAFKRDYKKCAVDSLSSELIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKMGDDKLELLR
IGTHSNLFG

Download         Length: 270 bp

>T64837 NZ_CP016606:c1851654-1851385 [Mannheimia granulomatis]
ATGAGAGAAATTGAGTATAGTAATGCTTTTAAACGGGATTATAAAAAATGTGCGGTTGATTCTTTATCGTCCGAATTAAT
TGAAGCATTATATTTTCTGATTAATGATAAACCATTACCTGAAAAATACTGCGATCATGCTTTAACAGGTGAATGGAAAG
GTTTTAGAGATTGCCATATTCAGCCTGATTTAGTCCTTATTTATCGAAAGATGGGGGATGATAAGTTAGAGTTACTGAGA
ATCGGCACTCATTCCAACCTATTTGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9788.16 Da        Isoelectric Point: 4.8141

>AT64837 WP_176670575.1 NZ_CP016606:c1851907-1851641 [Mannheimia granulomatis]
MANSALVSVRINPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETSEVLRAVKSGEEKLNSAKSIGDL
MEQLNERN

Download         Length: 267 bp

>AT64837 NZ_CP016606:c1851907-1851641 [Mannheimia granulomatis]
ATGGCAAATAGTGCATTAGTAAGTGTAAGAATTAATCCTGAAATTAAAGAGCAGGCAAGCGAAGTCCTAGCTGGGATTGG
CTTGACGGTTTCTGATGTAATGCGAATGACATTAGCTAAAATTGCGACCGAAAAACGCTTTCAGTTTGATTATCAACCTA
ATTTTGAAACGTCGGAAGTGCTAAGGGCAGTTAAGAGCGGAGAGGAAAAATTAAATTCAGCCAAAAGTATTGGGGATTTA
ATGGAGCAGCTCAATGAGAGAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References