Detailed information of TA system TA064836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 431244..431841
• Replicon: chromosome
• Accession: NZ_CP016606
• Organism: Mannheimia granulomatis strain BJ1680.3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A6B39_RS02275
• Protein ID: WP_176669559.1
• Coordinates: 431244..431519 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: A6B39_RS02280
• Protein ID: WP_025235602.1
• Coordinates: 431512..431841 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6B39_RS02260	427085..427798	-	714	WP_176669556.1	bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG	-
A6B39_RS02265	427862..428242	+	381	WP_176669557.1	pyrimidine dimer DNA glycosylase/endonuclease V	-
A6B39_RS02270	428353..431046	+	2694	WP_176669558.1	DNA topoisomerase (ATP-hydrolyzing) subunit A	-
A6B39_RS02275	431244..431519	+	276	WP_176669559.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6B39_RS02280	431512..431841	+	330	WP_025235602.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6B39_RS02285	431923..433479	-	1557	WP_176669560.1	type I restriction-modification system subunit M	-
A6B39_RS02290	433536..434711	-	1176	WP_176669561.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (28-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10458.16 Da
• Isoelectric Point: 9.6576

>T64836 WP_176669559.1 NZ_CP016606:431244-431519 [Mannheimia granulomatis]
MVLIHLKRKSHKTLRQIYTQPISANIKWRDIEALFLELGAEIEEREGSRIAVVLFEQVRVFHIPHPNPDTDKGAVASIKK
WLSENGVIPYA

Nucleotide

• Length: 276 bp

>T64836 NZ_CP016606:431244-431519 [Mannheimia granulomatis]
ATGGTATTAATTCATCTAAAGCGAAAATCTCACAAAACGTTACGTCAAATTTATACACAGCCCATTTCAGCCAATATTAA
GTGGAGAGATATTGAAGCTCTATTTCTTGAGTTAGGGGCTGAGATTGAAGAGCGAGAAGGTAGCCGAATTGCGGTTGTGT
TATTTGAGCAAGTCCGAGTTTTTCATATACCTCACCCAAATCCCGATACCGATAAAGGTGCGGTAGCAAGTATCAAAAAA
TGGTTATCTGAAAACGGAGTGATTCCTTATGCGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12264.05 Da
• Isoelectric Point: 4.8839

>AT64836 WP_025235602.1 NZ_CP016606:431512-431841 [Mannheimia granulomatis]
MRNIMEINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVAQLKKEGEISLNVFLEMCEKKNIEPFKQYSGKFNIRLSP
ELHKAAVMAATAENLSLNEWISQTLAKSV

Nucleotide

• Length: 330 bp

>AT64836 NZ_CP016606:431512-431841 [Mannheimia granulomatis]
ATGCGTAATATTATGGAAATTAATGGCTATAAAGCTGTGATTGCATACGATCCTGAAACCGAATTATTTAGAGGCGAATT
TATTGGCTTAAATGGTGGAGCAGATTTCTATGCAGATAATGTTGCCCAACTTAAGAAAGAAGGCGAAATCAGCCTAAACG
TTTTTCTCGAAATGTGTGAAAAGAAAAATATTGAGCCATTTAAACAGTATTCTGGCAAGTTTAACATTCGCCTATCACCA
GAACTACATAAAGCAGCTGTTATGGCAGCAACAGCAGAAAATTTAAGTTTGAATGAATGGATTAGCCAAACATTAGCAAA
AAGCGTGTGA