Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4934124..4935079 Replicon chromosome
Accession NZ_CP016594
Organism Gordonia terrae strain 3612

Toxin (Protein)


Gene name pezT Uniprot ID A0A4V0B4G9
Locus tag BCM27_RS21845 Protein ID WP_004022298.1
Coordinates 4934124..4934699 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A4V0B2G5
Locus tag BCM27_RS21850 Protein ID WP_004022299.1
Coordinates 4934696..4935079 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCM27_RS21815 4929586..4930593 + 1008 WP_004022292.1 LacI family transcriptional regulator -
BCM27_RS21820 4930616..4931296 - 681 WP_033204814.1 hypothetical protein -
BCM27_RS21825 4931395..4931709 - 315 WP_004022294.1 DUF2470 domain-containing protein -
BCM27_RS21830 4931702..4932433 - 732 WP_004022295.1 tyrosine-protein phosphatase -
BCM27_RS21835 4932526..4933158 + 633 WP_004022296.1 flavin reductase family protein -
BCM27_RS21840 4933180..4934127 - 948 WP_004022297.1 ribokinase -
BCM27_RS21845 4934124..4934699 - 576 WP_004022298.1 zeta toxin family protein Toxin
BCM27_RS21850 4934696..4935079 - 384 WP_004022299.1 hypothetical protein Antitoxin
BCM27_RS21855 4935203..4935751 - 549 WP_004022300.1 peptide-methionine (S)-S-oxide reductase MsrA -
BCM27_RS21860 4935748..4936230 - 483 WP_004022301.1 peptide-methionine (R)-S-oxide reductase MsrB -
BCM27_RS21865 4936390..4937613 - 1224 WP_051987126.1 acyl-CoA dehydrogenase family protein -
BCM27_RS21870 4937692..4938774 - 1083 WP_004022303.1 VOC family protein -
BCM27_RS21875 4939022..4939915 + 894 WP_004022304.1 acetaldehyde dehydrogenase (acetylating) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(2-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-62)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21075.04 Da        Isoelectric Point: 8.1649

>T64833 WP_004022298.1 NZ_CP016594:c4934699-4934124 [Gordonia terrae]
VTPRLDLVVGCNGAGKSTLVEHHLQPLVRTPFVNADLIARQQWPDAAEAHSYDAARLAAATRDHLIEAGASFIAETVFSH
PSKLELIDRAHTAGYRVALHVVMIPEDLAVHRVRLRVDSGGHAVPEVKIRERFRRLWPLVRTAILRSDQATVYANERATT
RIVARYVDGMVAGVPDWPDWTPGALTGSEAR

Download         Length: 576 bp

>T64833 NZ_CP016594:c4934699-4934124 [Gordonia terrae]
GTGACACCGAGGCTCGACCTGGTCGTCGGATGCAACGGCGCGGGAAAGTCGACGCTGGTCGAGCATCATCTACAGCCGTT
GGTGCGCACACCCTTCGTGAACGCCGACCTGATCGCCCGGCAGCAGTGGCCCGACGCCGCGGAAGCCCACTCCTACGACG
CGGCCCGGTTGGCCGCGGCCACCCGCGACCACCTCATCGAGGCCGGTGCCTCGTTCATCGCCGAGACGGTCTTCTCGCAT
CCGTCGAAACTGGAACTCATCGACCGTGCGCACACCGCCGGATACCGGGTCGCTCTCCATGTCGTGATGATCCCCGAAGA
TCTCGCCGTGCATCGGGTGCGGCTACGCGTCGACAGTGGGGGGCATGCGGTCCCGGAGGTCAAGATCCGCGAGCGGTTCC
GACGCCTGTGGCCGCTCGTCCGCACGGCGATCCTGCGGAGTGACCAGGCAACCGTGTACGCCAACGAGCGAGCGACCACG
CGCATCGTCGCGAGGTACGTCGACGGTATGGTCGCGGGCGTGCCCGACTGGCCCGACTGGACGCCGGGGGCGCTCACGGG
TTCGGAGGCACGATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13813.28 Da        Isoelectric Point: 5.2682

>AT64833 WP_004022299.1 NZ_CP016594:c4935079-4934696 [Gordonia terrae]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRRRVEAALAGDLPAETLTAEEAVVYDAEI
DAHIEARLATDDHVVRRASEGFASVVVDDAGRLVELRPDGTSVVFDR

Download         Length: 384 bp

>AT64833 NZ_CP016594:c4935079-4934696 [Gordonia terrae]
ATGAGCACCGGTACGGACAAGGTGACCCGATTGTCTGCTGCACTGGTGACCGATGCCGCCCGGGAGGGCGCGCGCGAGCA
GCGATCGGCGCGGCAGCAACTCGAACACTGGGCACGTCTCGGCCGCAGCGTCTCACAGCGCACCACCGCGTCGCGTCGGC
GGGTCGAGGCCGCGTTGGCCGGCGACCTACCGGCAGAGACGTTGACCGCAGAGGAAGCCGTCGTCTACGACGCCGAGATC
GACGCGCACATCGAGGCGCGGCTGGCCACCGACGACCATGTCGTCCGACGCGCCTCGGAGGGGTTCGCCTCGGTCGTCGT
CGATGACGCCGGACGGCTCGTCGAACTCCGGCCCGACGGGACGAGCGTCGTCTTCGACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0B4G9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0B2G5

References