Detailed information of TA system TA064827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 22276..22798
• Replicon: plasmid pSH13-006_37
• Accession: NZ_CP016580
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg strain SH13-006

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: A6W03_RS23090
• Protein ID: WP_000220560.1
• Coordinates: 22276..22557 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: A6W03_RS23095
• Protein ID: WP_000121743.1
• Coordinates: 22547..22798 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6W03_RS23055	18124..19290	-	1167	WP_000539532.1	relaxase/mobilization nuclease domain-containing protein	-
A6W03_RS23060	19293..19838	-	546	WP_000757693.1	hypothetical protein	-
A6W03_RS25380	19833..19907	-	75	Protein_23	DNA distortion polypeptide 3	-
A6W03_RS24540	20164..20436	-	273	WP_000160399.1	hypothetical protein	-
A6W03_RS25270	20449..20598	-	150	WP_000003880.1	hypothetical protein	-
A6W03_RS24545	20668..20847	-	180	WP_000439078.1	hypothetical protein	-
A6W03_RS23070	20890..21219	-	330	WP_000866646.1	hypothetical protein	-
A6W03_RS23075	21312..21527	-	216	WP_001180116.1	hypothetical protein	-
A6W03_RS23080	21517..21762	-	246	WP_000356547.1	hypothetical protein	-
A6W03_RS23085	21807..22130	-	324	WP_001181903.1	hypothetical protein	-
A6W03_RS23090	22276..22557	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6W03_RS23095	22547..22798	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
A6W03_RS23100	24032..24868	+	837	WP_001050931.1	replication initiation protein	-
A6W03_RS23105	24908..25354	+	447	WP_001074386.1	hypothetical protein	-
A6W03_RS23110	25422..25847	+	426	WP_000202944.1	hypothetical protein	-
A6W03_RS23115	25844..26821	-	978	WP_001269910.1	hypothetical protein	-
A6W03_RS23120	26846..27127	-	282	WP_001185482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37696	37696

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-126)

Antitoxin

• SpoVT-AbrB domain (6-43)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T64827 WP_000220560.1 NZ_CP016580:c22557-22276 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T64827 NZ_CP016580:c22557-22276 [Salmonella enterica subsp. enterica serovar Heidelberg]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT64827 WP_000121743.1 NZ_CP016580:c22798-22547 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT64827 NZ_CP016580:c22798-22547 [Salmonella enterica subsp. enterica serovar Heidelberg]
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301