Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1234..1756 Replicon plasmid pAMR588-04-00435_37
Accession NZ_CP016575
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain AMR588-04-00435

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag BAT64_RS22945 Protein ID WP_000220560.1
Coordinates 1475..1756 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag BAT64_RS22940 Protein ID WP_000121743.1
Coordinates 1234..1485 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAT64_RS22940 1234..1485 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
BAT64_RS22945 1475..1756 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BAT64_RS22950 1902..2225 + 324 WP_001181903.1 hypothetical protein -
BAT64_RS22955 2270..2515 + 246 WP_000356547.1 hypothetical protein -
BAT64_RS22960 2505..2720 + 216 WP_001180116.1 hypothetical protein -
BAT64_RS22965 2813..3142 + 330 WP_000866646.1 hypothetical protein -
BAT64_RS24540 3185..3364 + 180 WP_000439078.1 hypothetical protein -
BAT64_RS25250 3386..3583 + 198 WP_001675595.1 hypothetical protein -
BAT64_RS24545 3596..3868 + 273 WP_000160399.1 hypothetical protein -
BAT64_RS25360 4125..4199 + 75 Protein_9 DNA distortion polypeptide 3 -
BAT64_RS22975 4194..4739 + 546 WP_000757693.1 hypothetical protein -
BAT64_RS22980 4742..5908 + 1167 WP_000539532.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37697 37697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T64825 WP_000220560.1 NZ_CP016575:1475-1756 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T64825 NZ_CP016575:1475-1756 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT64825 WP_000121743.1 NZ_CP016575:1234-1485 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT64825 NZ_CP016575:1234-1485 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References