Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1238775..1240324 Replicon chromosome
Accession NZ_CP016556
Organism Vibrio coralliilyticus strain 58

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BA953_RS05500 Protein ID WP_065740599.1
Coordinates 1239023..1240324 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BA953_RS05495 Protein ID WP_065740598.1
Coordinates 1238775..1239023 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA953_RS05465 1234322..1234903 - 582 WP_065740593.1 recombinase family protein -
BA953_RS05470 1235070..1236170 - 1101 WP_065741726.1 tyrosine-type recombinase/integrase -
BA953_RS05475 1236160..1236648 - 489 WP_065740594.1 helix-turn-helix domain-containing protein -
BA953_RS05480 1236641..1236841 - 201 WP_065740595.1 AlpA family transcriptional regulator -
BA953_RS05485 1236931..1237860 - 930 WP_065740596.1 hypothetical protein -
BA953_RS05490 1238209..1238547 - 339 WP_155759882.1 hypothetical protein -
BA953_RS05495 1238775..1239023 + 249 WP_065740598.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
BA953_RS05500 1239023..1240324 + 1302 WP_065740599.1 type II toxin-antitoxin system HipA family toxin Toxin
BA953_RS05505 1240661..1240891 + 231 Protein_1111 integrase arm-type DNA-binding domain-containing protein -
BA953_RS05510 1241043..1242011 - 969 WP_065740601.1 helix-turn-helix domain-containing protein -
BA953_RS05515 1242161..1242931 + 771 WP_065740602.1 MBL fold metallo-hydrolase -
BA953_RS25375 1243465..1243926 + 462 Protein_1114 HipA domain-containing protein -
BA953_RS25070 1244132..1244296 - 165 Protein_1115 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1221110..1254499 33389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48613.42 Da        Isoelectric Point: 8.1984

>T64815 WP_065740599.1 NZ_CP016556:1239023-1240324 [Vibrio coralliilyticus]
MQKLIAYMNGELVGTLEKHKNGAHTFQYDKNWLTKAVTRPLSLSLKLQLPVITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALLPPELPYKKEPLSYEVLDDKKLEAVLSAYKSDIPLGMLEEEEDFRISVAGAQEKTAL
LFVDEQWCIPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELAKALGFAVPNVNIIKTDSIKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMELLMGSSNALEDRYNFMRFQVFQWLIGATDGHAKNFSIYID
KGGSYRLTPFYDILSAYPLLGGKGLNIRKLKLAMGLKATKGKKYEISKILPRHFLDTAKDVNFNQDTMQEIIDEMKDALP
KAMLQVSATLPKGFPEHIVGSIFENTQKIVKKI

Download         Length: 1302 bp

>T64815 NZ_CP016556:1239023-1240324 [Vibrio coralliilyticus]
ATGCAGAAGCTAATCGCATACATGAATGGTGAACTTGTTGGTACTCTAGAGAAACATAAGAATGGTGCTCACACTTTTCA
ATATGATAAAAACTGGTTAACCAAGGCGGTAACTCGACCACTATCATTGTCTTTGAAACTTCAATTACCAGTTATCACTT
CCGATGCGGTTATCAACTATTTTGACAATCTCTTGCCAGACAGCCCTCAAGTCAGAGATAGAATCGTTGCAAGGTACAAG
GCGTCATCCAAACAACCATTTGATCTCCTAAAAGAAATAGGAAAAGACAGTGTTGGTGCGATTGCTTTACTTCCTCCAGA
ACTCCCTTATAAAAAAGAACCACTTAGCTACGAAGTCCTGGATGACAAAAAACTAGAAGCTGTCCTTTCCGCATACAAGT
CTGATATTCCGCTCGGGATGCTCGAAGAAGAAGAGGACTTTAGAATCTCCGTGGCAGGTGCTCAAGAGAAAACGGCTCTC
CTATTTGTTGATGAGCAATGGTGTATACCGAAAGGAAACACACCCACCACTCACATCATCAAACTGCCAATAGGTGAAAT
ACAACAAGCTAACGCGACCTTAGATCTCAAAGATAGCGTAGAAAACGAGTACCTTTGTATTGAACTAGCTAAAGCACTGG
GGTTCGCAGTTCCCAACGTCAATATAATCAAAACAGACAGCATTAAAGCTTTAGCTGTGGAGCGCTTTGATAGGCGCTGG
ACAAAAGACAGAGCAGGATTACTACGCTTGCCTCAGGAAGATATCTGCCAAGTATTTGGTATGCCCTCATCCATTAAGTA
CGAATCTCAAGGTGGCCCTGGCATAGCTCAGATCATGGAGTTGTTAATGGGGTCAAGTAATGCCCTAGAAGATCGATATA
ACTTCATGAGGTTCCAAGTATTTCAATGGCTCATTGGCGCTACAGATGGACATGCTAAAAACTTTTCTATCTATATTGAT
AAAGGAGGCAGCTACAGACTCACTCCATTCTACGATATTTTGTCAGCCTACCCACTACTGGGAGGAAAAGGGCTCAATAT
CAGAAAGCTTAAGCTGGCGATGGGATTGAAAGCAACAAAGGGCAAGAAGTATGAAATCAGTAAAATCCTCCCTCGTCACT
TTTTGGATACAGCTAAAGATGTAAACTTTAATCAAGACACGATGCAAGAGATAATTGATGAAATGAAAGATGCCTTACCT
AAGGCGATGTTACAGGTAAGTGCTACATTGCCTAAAGGCTTTCCTGAGCATATCGTGGGCTCAATTTTTGAGAATACTCA
GAAAATAGTTAAGAAGATTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9323.63 Da        Isoelectric Point: 6.2564

>AT64815 WP_065740598.1 NZ_CP016556:1238775-1239023 [Vibrio coralliilyticus]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLAQAMDLTLSIQEKSQVASLNENDDE
SW

Download         Length: 249 bp

>AT64815 NZ_CP016556:1238775-1239023 [Vibrio coralliilyticus]
ATGATATATAGTCCAAAACAACTAGCAGATATGATGCTACTAATACGCCAGAAGAATGGATGGACACAGTCAGAACTAGC
AAAAAAAGTCGGCATCAAGCAAGCTACAATCTCGAACTTCGAAAACAACCCTAACAAAACAACACTTTCTACCTTCTTCA
AACTTGCCCAGGCAATGGACCTAACATTGAGTATCCAAGAAAAATCACAGGTCGCTTCATTAAATGAAAATGATGATGAG
AGTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References