Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 557028..557556 Replicon chromosome
Accession NZ_CP016556
Organism Vibrio coralliilyticus strain 58

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag BA953_RS02545 Protein ID WP_005377002.1
Coordinates 557266..557556 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag BA953_RS02540 Protein ID WP_005377003.1
Coordinates 557028..557276 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA953_RS25000 553700..553792 - 93 WP_004402681.1 DUF3265 domain-containing protein -
BA953_RS02520 553807..553977 - 171 WP_155759875.1 hypothetical protein -
BA953_RS02530 554069..555219 + 1151 WP_155759876.1 IS3 family transposase -
BA953_RS02535 555329..556369 + 1041 WP_065740104.1 IS481 family transposase -
BA953_RS02540 557028..557276 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BA953_RS02545 557266..557556 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BA953_RS25005 557575..557667 - 93 WP_196769793.1 DUF3265 domain-containing protein -
BA953_RS02550 557688..558251 - 564 WP_065740292.1 hypothetical protein -
BA953_RS25010 558278..558367 - 90 WP_081305575.1 DUF3265 domain-containing protein -
BA953_RS25335 558496..558789 + 294 WP_155759877.1 hypothetical protein -
BA953_RS25020 559885..560010 - 126 WP_081305526.1 DUF3265 domain-containing protein -
BA953_RS02560 560004..560423 - 420 WP_065740293.1 hypothetical protein -
BA953_RS02565 561082..561573 - 492 WP_065740294.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 538241..569189 30948
- inside Integron - - 541734..572007 30273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T64814 WP_005377002.1 NZ_CP016556:557266-557556 [Vibrio coralliilyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T64814 NZ_CP016556:557266-557556 [Vibrio coralliilyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCAACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTGGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AACTCCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGTGAACGTAGCGATGTTTACCGTAAAGCTATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT64814 WP_005377003.1 NZ_CP016556:557028-557276 [Vibrio coralliilyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT64814 NZ_CP016556:557028-557276 [Vibrio coralliilyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTACTGAACCGAAATGAACCAGCATTTTATTGCGTACCTGCAGAAGCATACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATTGCGAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References