Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1779581..1780110 Replicon plasmid plas1
Accession NZ_CP016555
Organism Ralstonia solanacearum FJAT-1458

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BCR16_RS26165 Protein ID WP_016722340.1
Coordinates 1779883..1780110 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BCR16_RS26160 Protein ID WP_016722339.1
Coordinates 1779581..1779886 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCR16_RS26135 1774685..1774966 - 282 WP_016722336.1 hypothetical protein -
BCR16_RS26140 1775097..1775381 - 285 WP_011003391.1 hypothetical protein -
BCR16_RS26145 1775833..1776819 + 987 WP_016721870.1 IS5 family transposase -
BCR16_RS28310 1776964..1777115 + 152 Protein_1433 IS5/IS1182 family transposase -
BCR16_RS26150 1777282..1777950 + 669 WP_038938024.1 hypothetical protein -
BCR16_RS26155 1778055..1779368 - 1314 WP_038938025.1 metabolite/H+ symporter -
BCR16_RS26160 1779581..1779886 - 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
BCR16_RS26165 1779883..1780110 - 228 WP_016722340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BCR16_RS26170 1780265..1781464 - 1200 WP_016726513.1 MFS transporter -
BCR16_RS26175 1781591..1782412 - 822 WP_011003398.1 GntR family transcriptional regulator -
BCR16_RS26180 1782590..1783141 - 552 WP_016722343.1 helix-turn-helix transcriptional regulator -
BCR16_RS26185 1783274..1783873 + 600 WP_016722344.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA / cyaB 1..2075659 2075659
- flank IS/Tn - - 1775833..1776819 986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-67)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8566.85 Da        Isoelectric Point: 7.2789

>T64812 WP_016722340.1 NZ_CP016555:c1780110-1779883 [Ralstonia solanacearum FJAT-1458]
VRIDRLQMGHPGNMKAVRDGIRELRIDHGPGDRLYFVRHGVVLIVLLCGGDKSTQETDIRRAIDLSRRLDVDDME

Download         Length: 228 bp

>T64812 NZ_CP016555:c1780110-1779883 [Ralstonia solanacearum FJAT-1458]
GTGCGCATCGACCGCCTGCAGATGGGCCACCCAGGCAACATGAAAGCGGTCCGTGACGGCATCCGTGAGCTGCGGATCGA
TCATGGGCCGGGCGACCGCTTGTACTTCGTGCGGCATGGCGTGGTCCTGATCGTACTGCTCTGCGGCGGCGACAAGTCGA
CGCAGGAAACCGATATCCGTCGCGCAATTGACCTGTCCCGCCGTCTCGACGTGGACGACATGGAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT64812 WP_016722339.1 NZ_CP016555:c1779886-1779581 [Ralstonia solanacearum FJAT-1458]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT64812 NZ_CP016555:c1779886-1779581 [Ralstonia solanacearum FJAT-1458]
ATGACGATGGCCCAACGCACCATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTCCGGACCGAAGCGGACATCGCCGC
CTACCTCGACGCCTGCCTGGAAGAAGCCGGAGATGACCCCGCCTTCATCACGCATGCGCTGGGCGTGGTCGCGCGCTCGC
GCGGCATGACGCAGCTCGCCCGCGAGACCGGGATGACCCGCGAGGGGCTGTACAAGGCGCTTTCCGAGGGCGGCAATCCG
AGCTTTGCGACCGTGCTGAAGGTCATCCGGGCGCTCGGCATCCGGCTGCACGCCGTGCCGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References