Detailed information of TA system TA064810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1953457..1954051
• Replicon: chromosome
• Accession: NZ_CP016554
• Organism: Ralstonia solanacearum FJAT-1458

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G3A6N4
• Locus tag: BCR16_RS09520
• Protein ID: WP_016721901.1
• Coordinates: 1953788..1954051 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BCR16_RS09515
• Protein ID: WP_038961924.1
• Coordinates: 1953457..1953795 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCR16_RS09485	1949839..1950177	+	339	WP_016721894.1	phage tail protein	-
BCR16_RS09490	1950174..1950851	+	678	WP_016721895.1	phage tail protein	-
BCR16_RS09495	1950857..1951453	+	597	WP_016721896.1	tail fiber assembly protein	-
BCR16_RS09500	1951450..1952151	+	702	WP_071895496.1	phage minor tail protein L	-
BCR16_RS09505	1952153..1952863	+	711	WP_071895497.1	C40 family peptidase	-
BCR16_RS09510	1952867..1953460	+	594	WP_016721899.1	tail assembly protein	-
BCR16_RS09515	1953457..1953795	-	339	WP_038961924.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BCR16_RS09520	1953788..1954051	-	264	WP_016721901.1	type II toxin-antitoxin system HicA family toxin	Toxin
BCR16_RS09525	1954104..1957259	+	3156	WP_016721902.1	host specificity protein J	-
BCR16_RS09535	1957596..1958252	+	657	WP_038961925.1	hypothetical protein	-
BCR16_RS09540	1958321..1958812	+	492	WP_038961926.1	glycoside hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1884025..1958812	74787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.30 Da
• Isoelectric Point: 8.7458

>T64810 WP_016721901.1 NZ_CP016554:c1954051-1953788 [Ralstonia solanacearum FJAT-1458]
MKAKHKKTLDLIFSRPTPAGVKWNDLVGLLVELGAEITEREGSRVAVFLFNQVKVMHRPHPSPDVDKGAVASIRKWLEDN
ATEWNNE

Nucleotide

• Length: 264 bp

>T64810 NZ_CP016554:c1954051-1953788 [Ralstonia solanacearum FJAT-1458]
ATGAAAGCCAAACACAAAAAGACGTTGGACCTGATCTTTTCCCGACCGACCCCGGCGGGGGTCAAATGGAACGACTTGGT
CGGTCTGCTGGTTGAGCTTGGCGCCGAGATCACCGAGCGGGAAGGCTCACGGGTTGCTGTGTTCCTGTTCAATCAGGTGA
AGGTGATGCACAGGCCGCACCCGTCCCCAGACGTGGACAAAGGCGCGGTCGCCTCGATCCGAAAGTGGCTCGAAGACAAC
GCAACGGAGTGGAACAATGAATAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12183.80 Da
• Isoelectric Point: 4.8946

>AT64810 WP_038961924.1 NZ_CP016554:c1953795-1953457 [Ralstonia solanacearum FJAT-1458]
MNNVMIIGGEKAVISFDPELEMFRGEFIGLNGGADFYASDVAGLHREGELSLRTFMEECVRRGVEPRRSFSGKFVLRTSE
KTHEAAAIAAAAHGVSLNQWVSDVIEQAAIPA

Nucleotide

• Length: 339 bp

>AT64810 NZ_CP016554:c1953795-1953457 [Ralstonia solanacearum FJAT-1458]
ATGAATAACGTCATGATCATCGGCGGCGAAAAAGCCGTCATTTCCTTCGATCCGGAACTGGAAATGTTTCGCGGCGAATT
CATCGGCCTGAATGGCGGTGCGGATTTTTACGCCAGTGATGTGGCTGGCCTGCACCGTGAAGGCGAGCTGTCGCTTCGCA
CCTTCATGGAGGAGTGCGTGCGCCGCGGCGTCGAACCGCGCCGCAGTTTCTCTGGCAAGTTCGTGTTACGCACGTCGGAG
AAGACACATGAAGCGGCCGCCATCGCCGCCGCCGCACATGGTGTGAGCCTGAACCAATGGGTGTCCGACGTGATCGAGCA
GGCCGCCATCCCGGCTTAA

Structures

Toxin

• AlphaFold DB: G3A6N4