Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YefM-YoeB
Location 2045083..2045585 Replicon chromosome
Accession NZ_CP016553
Organism Aggregatibacter actinomycetemcomitans strain IDH781

Toxin (Protein)


Gene name relE Uniprot ID A0A5D0ELA5
Locus tag BBH51_RS09920 Protein ID WP_005552753.1
Coordinates 2045083..2045334 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5D0ELP0
Locus tag BBH51_RS09925 Protein ID WP_005549367.1
Coordinates 2045331..2045585 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBH51_RS09900 2040392..2041582 - 1191 WP_005552755.1 hypothetical protein -
BBH51_RS09905 2041591..2042364 - 774 WP_180267045.1 glycosyltransferase family 25 protein -
BBH51_RS09910 2042498..2044021 + 1524 WP_005542228.1 hypothetical protein -
BBH51_RS09915 2044018..2044974 + 957 WP_005542226.1 polysaccharide pyruvyl transferase family protein -
BBH51_RS09920 2045083..2045334 + 252 WP_005552753.1 type II toxin-antitoxin system prevent-host-death family antitoxin Toxin
BBH51_RS09925 2045331..2045585 + 255 WP_005549367.1 Txe/YoeB family addiction module toxin Antitoxin
BBH51_RS09930 2045598..2046341 + 744 WP_005542222.1 YdcF family protein -
BBH51_RS09935 2046518..2047345 + 828 WP_005542220.1 DNA ligase -
BBH51_RS09940 2047477..2049651 - 2175 WP_005552750.1 DNA helicase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(1-84)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9414.65 Da        Isoelectric Point: 5.0637

>T64807 WP_005552753.1 NZ_CP016553:2045083-2045334 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQFNSGKIVERE
LQE

Download         Length: 252 bp

>T64807 NZ_CP016553:2045083-2045334 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGTCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGTTCAATTCAGGTAAAATCGTCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10203.68 Da        Isoelectric Point: 8.8844

>AT64807 WP_005549367.1 NZ_CP016553:2045331-2045585 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLVRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>AT64807 NZ_CP016553:2045331-2045585 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACAGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGGTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D0ELA5

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0ELP0

References