Detailed information of TA system TA064806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 2002286..2002878
• Replicon: chromosome
• Accession: NZ_CP016553
• Organism: Aggregatibacter actinomycetemcomitans strain IDH781

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BBH51_RS09705
• Protein ID: WP_005542431.1
• Coordinates: 2002579..2002878 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BBH51_RS09700
• Protein ID: WP_005542432.1
• Coordinates: 2002286..2002582 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBH51_RS09685	1997805..1999943	-	2139	WP_005542435.1	TonB-dependent siderophore receptor	-
BBH51_RS09690	2000215..2001612	-	1398	WP_005542434.1	MATE family efflux transporter	-
BBH51_RS09695	2001639..2002253	+	615	WP_005542433.1	riboflavin synthase	-
BBH51_RS09700	2002286..2002582	-	297	WP_005542432.1	putative addiction module antidote protein	Antitoxin
BBH51_RS09705	2002579..2002878	-	300	WP_005542431.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BBH51_RS09710	2003046..2003348	+	303	WP_005542430.1	ribosome assembly RNA-binding protein YhbY	-
BBH51_RS09715	2003424..2003900	-	477	WP_005542429.1	transcription elongation factor GreA	-
BBH51_RS09720	2004060..2005502	+	1443	WP_005542428.1	serine-type D-Ala-D-Ala carboxypeptidase	-
BBH51_RS09725	2005603..2006259	-	657	WP_005552874.1	GTP cyclohydrolase I FolE	-
BBH51_RS09730	2006388..2007602	+	1215	WP_005542426.1	molybdopterin molybdotransferase MoeA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-90)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11407.47 Da
• Isoelectric Point: 10.4825

>T64806 WP_005542431.1 NZ_CP016553:c2002878-2002579 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Nucleotide

• Length: 300 bp

>T64806 NZ_CP016553:c2002878-2002579 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCCAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGATAAA
TCCACTCAAGAGAAAGATATTAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10852.32 Da
• Isoelectric Point: 4.3776

>AT64806 WP_005542432.1 NZ_CP016553:c2002582-2002286 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Nucleotide

• Length: 297 bp

>AT64806 NZ_CP016553:c2002582-2002286 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAAATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAGGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATTGCACGAGCCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTACGCTTCTTAG