Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1732420..1732954 Replicon chromosome
Accession NZ_CP016553
Organism Aggregatibacter actinomycetemcomitans strain IDH781

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag BBH51_RS08450 Protein ID WP_005540089.1
Coordinates 1732664..1732954 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5D0EPW1
Locus tag BBH51_RS08445 Protein ID WP_005540091.1
Coordinates 1732420..1732674 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBH51_RS08415 1728145..1729242 + 1098 WP_005540103.1 histidinol-phosphate transaminase -
BBH51_RS08420 1729253..1730584 + 1332 WP_005551990.1 3-phosphoshikimate 1-carboxyvinyltransferase -
BBH51_RS08425 1730672..1731139 - 468 WP_005540098.1 ribonuclease HI -
BBH51_RS08430 1731207..1731968 + 762 WP_005540094.1 DNA polymerase III subunit epsilon -
BBH51_RS08445 1732420..1732674 + 255 WP_005540091.1 hypothetical protein Antitoxin
BBH51_RS08450 1732664..1732954 + 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBH51_RS08455 1733016..1733354 - 339 WP_005540087.1 cupin domain-containing protein -
BBH51_RS08460 1733695..1734138 + 444 WP_005552694.1 YeeE/YedE family protein -
BBH51_RS08465 1734310..1735698 + 1389 WP_005552695.1 tRNA 5-hydroxyuridine modification protein YegQ -
BBH51_RS08470 1736217..1737107 + 891 WP_005552698.1 WYL domain-containing transcriptional regulator -
BBH51_RS08475 1737146..1737532 + 387 WP_005540074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T64805 WP_005540089.1 NZ_CP016553:1732664-1732954 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T64805 NZ_CP016553:1732664-1732954 [Aggregatibacter actinomycetemcomitans]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGCAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCGGGCGACAAATTAAGAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAGACGCATATAAAAACGCAGAATTCAGACAAGCTCGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9275.49 Da        Isoelectric Point: 3.9645

>AT64805 WP_005540091.1 NZ_CP016553:1732420-1732674 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNHNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT64805 NZ_CP016553:1732420-1732674 [Aggregatibacter actinomycetemcomitans]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCATAACCAACCAGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0EPW1

References