Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1325410..1326007 Replicon chromosome
Accession NZ_CP016553
Organism Aggregatibacter actinomycetemcomitans strain IDH781

Toxin (Protein)


Gene name relE Uniprot ID A0A142FXE8
Locus tag BBH51_RS06525 Protein ID WP_005595366.1
Coordinates 1325705..1326007 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID G4A710
Locus tag BBH51_RS06520 Protein ID WP_005556438.1
Coordinates 1325410..1325703 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBH51_RS11410 1320992..1321278 + 287 Protein_1284 DNA-binding transcriptional regulator -
BBH51_RS06495 1321341..1322342 - 1002 WP_005538156.1 site-specific integrase -
BBH51_RS06505 1322917..1323327 + 411 WP_005538154.1 CidA/LrgA family protein -
BBH51_RS06510 1323327..1324019 + 693 WP_005538152.1 CidB/LrgB family autolysis modulator -
BBH51_RS06515 1324021..1325373 + 1353 WP_005538151.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
BBH51_RS06520 1325410..1325703 - 294 WP_005556438.1 putative addiction module antidote protein Antitoxin
BBH51_RS06525 1325705..1326007 - 303 WP_005595366.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBH51_RS06530 1326160..1328106 + 1947 WP_005538140.1 ABC transporter ATP-binding protein -
BBH51_RS06535 1329314..1329550 + 237 WP_005538841.1 hypothetical protein -
BBH51_RS06540 1329685..1329897 + 213 WP_005538838.1 hypothetical protein -
BBH51_RS06545 1329901..1330650 + 750 WP_005538836.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11413.93 Da        Isoelectric Point: 5.8716

>T64802 WP_005595366.1 NZ_CP016553:c1326007-1325705 [Aggregatibacter actinomycetemcomitans]
MYIIEETEEFSNWLENLTDELAIVNIVARIERAKLGNFGDHKSVGNGVYEMRITKGKGYRIYYARKGGITYLLILGGDKS
SQEQDIQNAKALWQQIKNGE

Download         Length: 303 bp

>T64802 NZ_CP016553:c1326007-1325705 [Aggregatibacter actinomycetemcomitans]
ATGTATATAATTGAGGAAACGGAGGAATTCTCCAACTGGTTAGAGAATCTAACCGACGAACTTGCGATTGTGAATATTGT
TGCTCGAATCGAAAGGGCAAAGCTCGGCAATTTCGGTGATCATAAATCGGTGGGTAATGGCGTATATGAAATGCGAATTA
CAAAAGGGAAAGGCTATAGGATCTACTATGCCAGAAAAGGGGGTATTACTTATCTATTGATTCTTGGTGGCGATAAGTCA
AGCCAAGAACAAGATATTCAGAATGCAAAAGCACTATGGCAACAGATTAAAAACGGAGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10694.39 Da        Isoelectric Point: 6.3545

>AT64802 WP_005556438.1 NZ_CP016553:c1325703-1325410 [Aggregatibacter actinomycetemcomitans]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Download         Length: 294 bp

>AT64802 NZ_CP016553:c1325703-1325410 [Aggregatibacter actinomycetemcomitans]
ATGACAGTAACAACCCGAGAATTTGATGCAGCGCGTTATTTGAAAAATGAAAAAATGATGGCAATGTATCTTGAAACAGT
TTTAGAAGAAGGCACAACGGCTGAGTTTATACAAGCTCTGAATACGGTCGCAAGAGCAAAGGGCATGTCGGAACTGGCGG
AAAAAACCGGCATCGGACGTGAAAGTTTGTACAAAACCCTATCAAGTGAAAAACCACGTTTTGACACGATTCTAAAAATT
ATTTCAGCATTGGGGCTTAGCCTTTCTATTAATGCTAAAGATGCAGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FXE8

Antitoxin

Source ID Structure
AlphaFold DB A0A142FXE9

References