Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 898968..899772 Replicon chromosome
Accession NZ_CP016552
Organism Geobacillus stearothermophilus strain DSM 458

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag GS458_RS04840 Protein ID WP_095859068.1
Coordinates 898968..899387 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag GS458_RS04845 Protein ID WP_031212949.1
Coordinates 899377..899772 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS458_RS04820 894058..895482 - 1425 WP_095859065.1 amino acid permease -
GS458_RS18700 895537..895965 + 429 WP_033015848.1 hypothetical protein -
GS458_RS04825 896005..897699 + 1695 WP_095859066.1 M3 family oligoendopeptidase -
GS458_RS04830 897920..898438 + 519 WP_095859067.1 GNAT family N-acetyltransferase -
GS458_RS18880 898519..898610 + 92 Protein_865 ABC transporter ATP-binding protein -
GS458_RS04835 898602..898940 + 339 Protein_866 TetR/AcrR family transcriptional regulator -
GS458_RS04840 898968..899387 - 420 WP_095859068.1 DUF86 domain-containing protein Toxin
GS458_RS04845 899377..899772 - 396 WP_031212949.1 nucleotidyltransferase domain-containing protein Antitoxin
GS458_RS04850 899971..900570 - 600 WP_095859069.1 hypothetical protein -
GS458_RS04860 901323..903458 - 2136 WP_095859070.1 ATP-dependent Clp protease ATP-binding subunit -
GS458_RS04865 903726..904472 + 747 WP_050368423.1 FixH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(5-94)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15904.43 Da        Isoelectric Point: 8.2859

>T64797 WP_095859068.1 NZ_CP016552:c899387-898968 [Geobacillus stearothermophilus]
MKNDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNG

Download         Length: 420 bp

>T64797 NZ_CP016552:c899387-898968 [Geobacillus stearothermophilus]
ATGAAAAATGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAGGCATGCATCGATT
TGGCCATGCATATCGTGGCCGAGCAGAAATTCGGATTGCCGCAGCATAGCCGCGATGCATTCGCTCTCCTCGAAGAACAT
GGGGTCATCTCCCCTTCCATAAGCAAAAAGATGAAGGCGATGGTCGGATTCCGCAACATCGCCGTTCACGACTATCAACA
ACTGAACCTTGGCATCTTGCAAGCCATCGTCGAACACCATCTTGATGATTTCAAACAATTTACGAAAGCCATCCTCGATT
ATGCTAAGAAAAACGGCTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14797.97 Da        Isoelectric Point: 5.6982

>AT64797 WP_031212949.1 NZ_CP016552:c899772-899377 [Geobacillus stearothermophilus]
METIIIQTLRPALHPFVIYLFGSAARGAMRPDSDVDIAFVSDGEPHDPYELFRLAGHLADKLGRDVDLVDLRQASTVFQA
QVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK

Download         Length: 396 bp

>AT64797 NZ_CP016552:c899772-899377 [Geobacillus stearothermophilus]
ATGGAGACGATCATCATTCAGACGCTCCGCCCGGCTCTTCACCCGTTCGTCATCTACCTGTTCGGTTCAGCCGCCCGTGG
GGCGATGCGCCCGGACAGTGATGTCGATATCGCCTTTGTCAGCGACGGCGAACCGCATGATCCGTATGAGCTGTTTCGGC
TCGCGGGGCATTTGGCTGACAAGTTAGGGCGAGATGTCGATCTTGTCGATTTGCGCCAAGCCAGCACCGTGTTTCAAGCG
CAAGTCGTCTCGACGGGAAAAGCCATTGATTGCCGCGACGAGCGGAAACGGGCTGAGTTCGAAATGAAAACATTGAAAAT
GTATGTGAAACTAAACGAAGAGAGAGCACCGGTGTTAAAACAAATTACGGAAAGCGGGAGCATATATGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References