Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 46245..46780 Replicon plasmid unnamed2
Accession NZ_CP016548
Organism Escherichia coli strain O177:H21

Toxin (Protein)


Gene name relE Uniprot ID A0A2H5C122
Locus tag BB405_RS26725 Protein ID WP_001611950.1
Coordinates 46493..46780 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag BB405_RS26720 Protein ID WP_001132900.1
Coordinates 46245..46496 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB405_RS31235 41749..42210 - 462 WP_174843148.1 PilI type IV pilus biogenesis protein -
BB405_RS26700 42268..42933 - 666 WP_029391921.1 hypothetical protein -
BB405_RS26705 43075..43716 - 642 WP_077250484.1 transcription termination factor NusG -
BB405_RS26710 44417..45289 + 873 WP_021532687.1 incFII family plasmid replication initiator RepA -
BB405_RS26720 46245..46496 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BB405_RS26725 46493..46780 + 288 WP_001611950.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BB405_RS26730 46884..47474 + 591 WP_029391923.1 serine acetyltransferase -
BB405_RS26735 47577..48184 + 608 Protein_56 hypothetical protein -
BB405_RS32515 48385..48687 - 303 WP_001245884.1 hypothetical protein -
BB405_RS26745 48684..49310 - 627 WP_000587689.1 ParA family plasmid-partitioning AAA ATPase -
BB405_RS26750 49498..50769 - 1272 WP_000457521.1 Y-family DNA polymerase -
BB405_RS26755 50769..51206 - 438 WP_000109062.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
BB405_RS26760 51203..51451 - 249 WP_000618110.1 DinI-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 - 1..90835 90835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11139.17 Da        Isoelectric Point: 10.5832

>T64792 WP_001611950.1 NZ_CP016548:46493-46780 [Escherichia coli]
MTYTVKFRDDAFKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T64792 NZ_CP016548:46493-46780 [Escherichia coli]
ATGACTTATACAGTAAAATTCAGGGATGATGCGTTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT64792 WP_001132900.1 NZ_CP016548:46245-46496 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT64792 NZ_CP016548:46245-46496 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H5C122

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References