Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2006895..2007883 Replicon chromosome
Accession NZ_CP016546
Organism Escherichia coli strain O177:H21

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag BB405_RS10130 Protein ID WP_014640052.1
Coordinates 2006895..2007281 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0A1AFM1
Locus tag BB405_RS10135 Protein ID WP_000458583.1
Coordinates 2007311..2007883 (-) Length 191 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB405_RS10100 2002710..2003246 + 537 WP_000008232.1 5'-deoxynucleotidase -
BB405_RS10105 2003237..2003599 + 363 WP_001242725.1 hypothetical protein -
BB405_RS31710 2003599..2003970 + 372 Protein_1929 hypothetical protein -
BB405_RS10120 2005744..2006316 + 573 WP_001061342.1 3'-5' exoribonuclease -
BB405_RS10125 2006353..2006634 + 282 WP_001093916.1 pyocin activator PrtN family protein -
BB405_RS32295 2006682..2006855 - 174 WP_000390072.1 hypothetical protein -
BB405_RS10130 2006895..2007281 - 387 WP_014640052.1 hypothetical protein Toxin
BB405_RS10135 2007311..2007883 - 573 WP_000458583.1 SocA family protein Antitoxin
BB405_RS28765 2008119..2008241 - 123 WP_001300034.1 hypothetical protein -
BB405_RS10140 2008605..2009626 - 1022 Protein_1937 DUF2713 family protein -
BB405_RS10150 2009944..2010459 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
BB405_RS10155 2010501..2010710 - 210 WP_001030593.1 CsbD family protein -
BB405_RS10160 2010826..2012151 - 1326 WP_001347655.1 MATE family efflux transporter DinF -
BB405_RS10165 2012224..2012832 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1958068..2012832 54764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(27-137)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T64772 WP_014640052.1 NZ_CP016546:c2007281-2006895 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T64772 NZ_CP016546:c2007281-2006895 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21956.30 Da        Isoelectric Point: 6.0283

>AT64772 WP_000458583.1 NZ_CP016546:c2007883-2007311 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT64772 NZ_CP016546:c2007883-2007311 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AFM1

References