Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1691537..1692372 Replicon chromosome
Accession NZ_CP016546
Organism Escherichia coli strain O177:H21

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag BB405_RS08430 Protein ID WP_000854759.1
Coordinates 1691537..1691914 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag BB405_RS08435 Protein ID WP_001295723.1
Coordinates 1692004..1692372 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB405_RS08410 1687926..1689467 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
BB405_RS31615 1690061..1690237 - 177 Protein_1606 helix-turn-helix domain-containing protein -
BB405_RS32650 1690601..1690753 - 153 WP_011478345.1 hypothetical protein -
BB405_RS08420 1690859..1691035 - 177 WP_000839286.1 DUF957 domain-containing protein -
BB405_RS08425 1691052..1691540 - 489 WP_000761690.1 hypothetical protein -
BB405_RS08430 1691537..1691914 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
BB405_RS08435 1692004..1692372 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BB405_RS08445 1692535..1692756 - 222 WP_000692345.1 DUF987 domain-containing protein -
BB405_RS08450 1692819..1693295 - 477 WP_001186775.1 RadC family protein -
BB405_RS08455 1693311..1693784 - 474 WP_000855059.1 antirestriction protein -
BB405_RS08465 1694124..1694942 - 819 WP_042631095.1 DUF945 domain-containing protein -
BB405_RS08470 1695097..1695255 - 159 WP_001323397.1 DUF905 family protein -
BB405_RS08475 1695326..1696351 - 1026 Protein_1617 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T64769 WP_000854759.1 NZ_CP016546:c1691914-1691537 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T64769 NZ_CP016546:c1691914-1691537 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT64769 WP_001295723.1 NZ_CP016546:c1692372-1692004 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT64769 NZ_CP016546:c1692372-1692004 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References