Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 547924..548563 Replicon chromosome
Accession NZ_CP016539
Organism Planococcus plakortidis strain DSM 23997

Toxin (Protein)


Gene name pemK Uniprot ID A0A1C7EC77
Locus tag BBI15_RS02870 Protein ID WP_058381776.1
Coordinates 548213..548563 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1C7EBE9
Locus tag BBI15_RS02865 Protein ID WP_058381777.1
Coordinates 547924..548208 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBI15_RS02840 543617..544096 + 480 WP_068872080.1 PH domain-containing protein -
BBI15_RS02845 544089..545660 + 1572 WP_068872679.1 PH domain-containing protein -
BBI15_RS02850 545678..546292 - 615 WP_068872082.1 rhomboid family intramembrane serine protease -
BBI15_RS02855 546361..546714 + 354 WP_068872084.1 holo-ACP synthase -
BBI15_RS02860 546731..547879 + 1149 WP_068872087.1 alanine racemase -
BBI15_RS02865 547924..548208 + 285 WP_058381777.1 hypothetical protein Antitoxin
BBI15_RS02870 548213..548563 + 351 WP_058381776.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BBI15_RS02875 548742..549572 + 831 WP_068872088.1 STAS domain-containing protein -
BBI15_RS02880 549569..549931 + 363 WP_058381774.1 STAS domain-containing protein -
BBI15_RS02885 549934..550335 + 402 WP_058381773.1 anti-sigma regulatory factor -
BBI15_RS02890 550348..551349 + 1002 WP_068872091.1 PP2C family protein-serine/threonine phosphatase -
BBI15_RS02895 551444..551776 + 333 WP_068872093.1 anti-sigma factor antagonist -
BBI15_RS02900 551779..552249 + 471 WP_058381770.1 anti-sigma B factor RsbW -
BBI15_RS02905 552227..553009 + 783 WP_058381769.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12850.94 Da        Isoelectric Point: 5.8817

>T64760 WP_058381776.1 NZ_CP016539:548213-548563 [Planococcus plakortidis]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDALMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T64760 NZ_CP016539:548213-548563 [Planococcus plakortidis]
TTGATTGTAAAACGCGGGGATGTTTTTTTCGCAGAATTATCACCGGTCGTCGGGTCTGAGCAAGGCGGGACCCGTCCGGT
TTTGGTGATACAAAATGATATCGGTAACCGATTTAGCCCAACAGTGATCATAGCGGCGATCACCGCCCAGATCCAGAAAG
CCAAATTGCCGACCCACGTGGAGATCAATGCCAAGAAATACGGCTTTGAGCGTGATTCTGTTATTTTGCTTGAGCAATTG
CGGACAATTGATAAATCGCGTTTGACCGATAAGATTACACAGCTGGACGATGCGTTGATGGAAAAGGTGGACGAAGCCTT
GGAAATCAGTGTCGGACTTGTAAAGTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10763.11 Da        Isoelectric Point: 5.1572

>AT64760 WP_058381777.1 NZ_CP016539:547924-548208 [Planococcus plakortidis]
VYEKSKTKEVVVKLPKQFMSELTAHSDERIEENGEFIYVSTQRVTKNVYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVQLVSGG

Download         Length: 285 bp

>AT64760 NZ_CP016539:547924-548208 [Planococcus plakortidis]
GTGTACGAGAAGTCAAAGACGAAAGAAGTGGTAGTCAAGTTGCCGAAGCAATTCATGTCGGAGCTCACTGCCCATTCAGA
TGAACGCATAGAGGAGAACGGTGAATTCATCTATGTATCGACTCAACGGGTAACAAAAAATGTCTACGATTCATATCATA
TTCGGGAAGCGATGATCAAGGGCTACGTGGAAATGTCGCAGATCAACCTGTCGATTGCCTGCGAATGCTCGCACGCTGAG
TACGAAGCGGAGCACACGACAGTGCAACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7EC77

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7EBE9

References