Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 526856..527495 Replicon chromosome
Accession NZ_CP016538
Organism Planococcus maritimus strain DSM 17275

Toxin (Protein)


Gene name pemK Uniprot ID A0A1C7EC77
Locus tag BBI11_RS02765 Protein ID WP_058381776.1
Coordinates 527145..527495 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1C7DXF0
Locus tag BBI11_RS02760 Protein ID WP_068460417.1
Coordinates 526856..527140 (+) Length 95 a.a.

Genomic Context

BBI11_RS02735BBI11_RS02740BBI11_RS02750BBI11_RS02755BBI11_RS02760BBI11_RS02765BBI11_RS02770BBI11_RS02775BBI11_RS02780BBI11_RS02785BBI11_RS02790BBI11_RS02795BBI11_RS02800BBI11_RS02745
Location: 522551..523030 (480 bp)
Type: Others
Protein ID: WP_068460409.1
Location: 523023..524594 (1572 bp)
Type: Others
Protein ID: WP_068465558.1
Location: 525294..525647 (354 bp)
Type: Others
Protein ID: WP_068460414.1
Location: 525664..526812 (1149 bp)
Type: Others
Protein ID: WP_068460415.1
Location: 526856..527140 (285 bp)
Type: Antitoxin
Protein ID: WP_068460417.1
Location: 527145..527495 (351 bp)
Type: Toxin
Protein ID: WP_058381776.1
Location: 527673..528503 (831 bp)
Type: Others
Protein ID: WP_068460419.1
Location: 528500..528862 (363 bp)
Type: Others
Protein ID: WP_068460422.1
Location: 528865..529266 (402 bp)
Type: Others
Protein ID: WP_068460424.1
Location: 529279..530280 (1002 bp)
Type: Others
Protein ID: WP_068460426.1
Location: 530376..530708 (333 bp)
Type: Others
Protein ID: WP_068460429.1
Location: 530711..531181 (471 bp)
Type: Others
Protein ID: WP_068460431.1
Location: 531159..531941 (783 bp)
Type: Others
Protein ID: WP_068460433.1
Location: 524611..525225 (615 bp)
Type: Others
Protein ID: WP_068460411.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BBI11_RS02735522551..523030+480WP_068460409.1PH domain-containing protein-
BBI11_RS02740523023..524594+1572WP_068465558.1PH domain-containing protein-
BBI11_RS02745524611..525225-615WP_068460411.1rhomboid family intramembrane serine protease-
BBI11_RS02750525294..525647+354WP_068460414.1holo-ACP synthase-
BBI11_RS02755525664..526812+1149WP_068460415.1alanine racemase-
BBI11_RS02760526856..527140+285WP_068460417.1transcriptional regulatorAntitoxin
BBI11_RS02765527145..527495+351WP_058381776.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BBI11_RS02770527673..528503+831WP_068460419.1STAS domain-containing protein-
BBI11_RS02775528500..528862+363WP_068460422.1STAS domain-containing protein-
BBI11_RS02780528865..529266+402WP_068460424.1anti-sigma regulatory factor-
BBI11_RS02785529279..530280+1002WP_068460426.1PP2C family protein-serine/threonine phosphatase-
BBI11_RS02790530376..530708+333WP_068460429.1anti-sigma factor antagonist-
BBI11_RS02795530711..531181+471WP_068460431.1anti-sigma B factor RsbW-
BBI11_RS02800531159..531941+783WP_068460433.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12850.94 Da        Isoelectric Point: 5.8817

>T64759 WP_058381776.1 NZ_CP016538:527145-527495 [Planococcus maritimus]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDALMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T64759 NZ_CP016538:527145-527495 [Planococcus maritimus]
TTGATTGTAAAACGCGGGGATGTTTTTTTCGCAGAATTATCACCGGTCGTCGGGTCTGAGCAAGGCGGGACCCGTCCGGT
TTTGGTGATACAAAACGATATCGGGAACCGATTTAGTCCGACAGTGATCATTGCGGCGATCACCGCCCAGATCCAAAAAG
CCAAATTGCCGACACACGTAGAAATCAACGCCAAGAAATACGGATTTGAGCGTGACTCTGTAATTTTGCTTGAACAATTG
CGGACGATTGATAAATCGCGTTTGACTGATAAAATTACACAGCTGGACGATGCGTTGATGGAGAAGGTGGACGAAGCCTT
AGAAATCAGTGTCGGACTTGTAAAATTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10705.07 Da        Isoelectric Point: 5.5819

>AT64759 WP_068460417.1 NZ_CP016538:526856-527140 [Planococcus maritimus]
VYEKSKTKEVVVKLPKQFMSELTAHSGERIEENGEFIYVSTQRVTKNVYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVQLVSGG

Download         Length: 285 bp

>AT64759 NZ_CP016538:526856-527140 [Planococcus maritimus]
GTGTACGAGAAGTCAAAGACGAAAGAAGTGGTAGTCAAGTTGCCGAAGCAATTCATGTCGGAGCTTACTGCGCACTCAGG
TGAACGCATTGAGGAAAACGGTGAATTCATCTATGTATCGACTCAACGAGTAACAAAAAATGTCTACGATTCATATCATA
TTCGGGAAGCGATGATCAAGGGCTACGTGGAAATGTCGCAGATCAACCTGTCAATTGCCTGCGAATGTTCGCACGCTGAG
TACGAAGCGGAGCACACGACAGTGCAACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1C7EC77

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1C7DXF0

References