Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 526856..527495 Replicon chromosome
Accession NZ_CP016538
Organism Planococcus maritimus strain DSM 17275

Toxin (Protein)


Gene name pemK Uniprot ID A0A1C7EC77
Locus tag BBI11_RS02765 Protein ID WP_058381776.1
Coordinates 527145..527495 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1C7DXF0
Locus tag BBI11_RS02760 Protein ID WP_068460417.1
Coordinates 526856..527140 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBI11_RS02735 522551..523030 + 480 WP_068460409.1 PH domain-containing protein -
BBI11_RS02740 523023..524594 + 1572 WP_068465558.1 PH domain-containing protein -
BBI11_RS02745 524611..525225 - 615 WP_068460411.1 rhomboid family intramembrane serine protease -
BBI11_RS02750 525294..525647 + 354 WP_068460414.1 holo-ACP synthase -
BBI11_RS02755 525664..526812 + 1149 WP_068460415.1 alanine racemase -
BBI11_RS02760 526856..527140 + 285 WP_068460417.1 transcriptional regulator Antitoxin
BBI11_RS02765 527145..527495 + 351 WP_058381776.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BBI11_RS02770 527673..528503 + 831 WP_068460419.1 STAS domain-containing protein -
BBI11_RS02775 528500..528862 + 363 WP_068460422.1 STAS domain-containing protein -
BBI11_RS02780 528865..529266 + 402 WP_068460424.1 anti-sigma regulatory factor -
BBI11_RS02785 529279..530280 + 1002 WP_068460426.1 PP2C family protein-serine/threonine phosphatase -
BBI11_RS02790 530376..530708 + 333 WP_068460429.1 anti-sigma factor antagonist -
BBI11_RS02795 530711..531181 + 471 WP_068460431.1 anti-sigma B factor RsbW -
BBI11_RS02800 531159..531941 + 783 WP_068460433.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12850.94 Da        Isoelectric Point: 5.8817

>T64759 WP_058381776.1 NZ_CP016538:527145-527495 [Planococcus maritimus]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDALMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T64759 NZ_CP016538:527145-527495 [Planococcus maritimus]
TTGATTGTAAAACGCGGGGATGTTTTTTTCGCAGAATTATCACCGGTCGTCGGGTCTGAGCAAGGCGGGACCCGTCCGGT
TTTGGTGATACAAAACGATATCGGGAACCGATTTAGTCCGACAGTGATCATTGCGGCGATCACCGCCCAGATCCAAAAAG
CCAAATTGCCGACACACGTAGAAATCAACGCCAAGAAATACGGATTTGAGCGTGACTCTGTAATTTTGCTTGAACAATTG
CGGACGATTGATAAATCGCGTTTGACTGATAAAATTACACAGCTGGACGATGCGTTGATGGAGAAGGTGGACGAAGCCTT
AGAAATCAGTGTCGGACTTGTAAAATTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10705.07 Da        Isoelectric Point: 5.5819

>AT64759 WP_068460417.1 NZ_CP016538:526856-527140 [Planococcus maritimus]
VYEKSKTKEVVVKLPKQFMSELTAHSGERIEENGEFIYVSTQRVTKNVYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVQLVSGG

Download         Length: 285 bp

>AT64759 NZ_CP016538:526856-527140 [Planococcus maritimus]
GTGTACGAGAAGTCAAAGACGAAAGAAGTGGTAGTCAAGTTGCCGAAGCAATTCATGTCGGAGCTTACTGCGCACTCAGG
TGAACGCATTGAGGAAAACGGTGAATTCATCTATGTATCGACTCAACGAGTAACAAAAAATGTCTACGATTCATATCATA
TTCGGGAAGCGATGATCAAGGGCTACGTGGAAATGTCGCAGATCAACCTGTCAATTGCCTGCGAATGTTCGCACGCTGAG
TACGAAGCGGAGCACACGACAGTGCAACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7EC77

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7DXF0

References