Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 515882..516521 Replicon chromosome
Accession NZ_CP016537
Organism Planococcus halocryophilus strain DSM 24743

Toxin (Protein)


Gene name pemK Uniprot ID E7RK71
Locus tag BBI08_RS02685 Protein ID WP_008432415.1
Coordinates 516171..516521 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID E7RK70
Locus tag BBI08_RS02680 Protein ID WP_008432414.1
Coordinates 515882..516166 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBI08_RS02655 511603..512082 + 480 WP_008498821.1 PH domain-containing protein -
BBI08_RS02660 512075..513586 + 1512 WP_008498823.1 PH domain-containing protein -
BBI08_RS02665 513635..514243 - 609 WP_008498824.1 rhomboid family intramembrane serine protease -
BBI08_RS02670 514312..514665 + 354 WP_008498825.1 holo-ACP synthase -
BBI08_RS02675 514681..515838 + 1158 WP_065528466.1 alanine racemase -
BBI08_RS02680 515882..516166 + 285 WP_008432414.1 hypothetical protein Antitoxin
BBI08_RS02685 516171..516521 + 351 WP_008432415.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BBI08_RS02690 516684..517511 + 828 WP_008498826.1 STAS domain-containing protein -
BBI08_RS02695 517508..517873 + 366 WP_201764051.1 STAS domain-containing protein -
BBI08_RS02700 517876..518277 + 402 WP_008432420.1 anti-sigma regulatory factor -
BBI08_RS02705 518290..519291 + 1002 WP_008498828.1 PP2C family protein-serine/threonine phosphatase -
BBI08_RS02710 519388..519717 + 330 WP_008498829.1 anti-sigma factor antagonist -
BBI08_RS02715 519719..520189 + 471 WP_008498830.1 anti-sigma B factor RsbW -
BBI08_RS02720 520167..520949 + 783 WP_008498831.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12880.97 Da        Isoelectric Point: 5.8817

>T64758 WP_008432415.1 NZ_CP016537:516171-516521 [Planococcus halocryophilus]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDTLMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T64758 NZ_CP016537:516171-516521 [Planococcus halocryophilus]
TTGATTGTAAAACGCGGAGATGTTTTTTTTGCGGAATTATCGCCAGTCGTCGGGTCTGAGCAAGGTGGGACCCGCCCGGT
TCTGGTGATTCAAAACGATATAGGGAATCGATTTAGTCCCACCGTCATTATTGCTGCAATAACGGCACAGATTCAAAAAG
CTAAATTGCCGACTCATGTAGAAATCAATGCCAAAAAATATGGTTTTGAGCGTGATTCTGTTATTTTGCTTGAACAATTA
CGAACAATTGATAAGTCGAGATTAACCGACAAAATTACTCAACTTGACGACACATTGATGGAAAAAGTGGATGAAGCATT
GGAAATCAGCGTGGGCCTAGTGAAATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10689.03 Da        Isoelectric Point: 6.6344

>AT64758 WP_008432414.1 NZ_CP016537:515882-516166 [Planococcus halocryophilus]
VYGKSKTKEVVVKMPKQFISELTTHSNEHVQESGDYIYVSTNRVTKNLYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVRLVSGG

Download         Length: 285 bp

>AT64758 NZ_CP016537:515882-516166 [Planococcus halocryophilus]
GTGTACGGTAAGTCAAAGACAAAAGAAGTGGTTGTGAAAATGCCAAAGCAATTTATTTCGGAGTTGACAACTCATTCAAA
TGAGCATGTTCAGGAAAGTGGAGATTATATTTACGTTTCCACAAACCGGGTGACGAAAAATCTATACGACTCATATCATA
TTCGGGAAGCGATGATCAAGGGCTACGTGGAGATGTCACAAATCAATCTATCGATTGCTTGTGAATGTTCTCACGCTGAG
TACGAAGCGGAGCATACGACCGTGCGACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7DUM1

Antitoxin

Source ID Structure
AlphaFold DB E7RK70

References