Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 551640..552279 Replicon chromosome
Accession NZ_CP016534
Organism Planococcus antarcticus DSM 14505

Toxin (Protein)


Gene name mazF Uniprot ID A0A1C7DBN4
Locus tag BBH88_RS02880 Protein ID WP_006830187.1
Coordinates 551929..552279 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1C7DBJ9
Locus tag BBH88_RS02875 Protein ID WP_006830188.1
Coordinates 551640..551924 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBH88_RS02850 547358..547837 + 480 WP_065536184.1 PH domain-containing protein -
BBH88_RS02855 547830..549338 + 1509 WP_065537324.1 PH domain-containing protein -
BBH88_RS02860 549393..550001 - 609 WP_006830191.1 rhomboid family intramembrane serine protease -
BBH88_RS02865 550070..550423 + 354 WP_006830190.1 holo-ACP synthase -
BBH88_RS02870 550439..551596 + 1158 WP_065536183.1 alanine racemase -
BBH88_RS02875 551640..551924 + 285 WP_006830188.1 hypothetical protein Antitoxin
BBH88_RS02880 551929..552279 + 351 WP_006830187.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BBH88_RS02885 552448..553275 + 828 WP_006830186.1 STAS domain-containing protein -
BBH88_RS02890 553272..553637 + 366 WP_177167575.1 STAS domain-containing protein -
BBH88_RS02895 553640..554041 + 402 WP_006830184.1 anti-sigma regulatory factor -
BBH88_RS02900 554054..555055 + 1002 WP_006830183.1 PP2C family protein-serine/threonine phosphatase -
BBH88_RS02905 555154..555483 + 330 WP_006830182.1 anti-sigma factor antagonist -
BBH88_RS02910 555485..555955 + 471 WP_006830181.1 anti-sigma B factor RsbW -
BBH88_RS02915 555933..556715 + 783 WP_006830180.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12908.98 Da        Isoelectric Point: 5.8817

>T64757 WP_006830187.1 NZ_CP016534:551929-552279 [Planococcus antarcticus DSM 14505]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQL
RTIDKSRLTDKITQLDDTLMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T64757 NZ_CP016534:551929-552279 [Planococcus antarcticus DSM 14505]
TTGATTGTAAAACGCGGGGATGTTTTTTTTGCAGAATTATCACCGGTCGTCGGGTCTGAGCAAGGTGGGACCCGTCCTGT
CCTGGTGATTCAAAATGATATAGGCAATCGTTTCAGTCCTACTGTAATCATTGCTGCAATTACAGCGCAGATTCAAAAAG
CTAAATTGCCGACTCATGTGGAGATCAACGCCAAGAGGTATGGCTTTGAGCGTGATTCAGTTATTCTGCTTGAACAATTG
CGGACCATTGACAAGTCTCGACTGACCGATAAAATCACTCAACTTGATGACACGTTGATGGAAAAAGTGGACGAAGCATT
GGAAATTAGCGTTGGCCTCGTGAAATTTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10769.15 Da        Isoelectric Point: 6.6354

>AT64757 WP_006830188.1 NZ_CP016534:551640-551924 [Planococcus antarcticus DSM 14505]
VYEKSKTKEVVVKLPKQFISELTTHSDERVQESGDFIYVSTHRVTKNLYNSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVRLVSGG

Download         Length: 285 bp

>AT64757 NZ_CP016534:551640-551924 [Planococcus antarcticus DSM 14505]
GTGTACGAGAAGTCAAAAACAAAAGAAGTGGTTGTAAAATTGCCAAAACAATTTATTTCGGAGTTGACAACTCATTCAGA
TGAACGTGTTCAAGAAAGTGGAGATTTTATTTATGTTTCCACGCATCGGGTGACAAAGAATCTGTACAACTCATATCATA
TTCGGGAAGCGATGATCAAGGGCTACGTAGAGATGTCACAGATCAATCTATCGATTGCTTGTGAATGTTCTCACGCTGAG
TACGAAGCGGAGCACACGACAGTGCGACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7DBN4

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7DBJ9

References