Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 19943..20468 Replicon plasmid pSA02DT09004001_101
Accession NZ_CP016522
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain SA02DT09004001

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag BAT61_RS23075 Protein ID WP_001159871.1
Coordinates 20163..20468 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag BAT61_RS23070 Protein ID WP_000813630.1
Coordinates 19943..20161 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAT61_RS23040 14944..15534 - 591 WP_000194550.1 hypothetical protein -
BAT61_RS23045 15534..15788 - 255 WP_000343103.1 hypothetical protein -
BAT61_RS23050 16140..17141 + 1002 WP_000774875.1 DUF4238 domain-containing protein -
BAT61_RS23055 17317..17661 - 345 WP_000793307.1 hypothetical protein -
BAT61_RS23060 18160..18414 - 255 WP_000678527.1 hypothetical protein -
BAT61_RS23065 18459..19385 - 927 WP_001290416.1 hypothetical protein -
BAT61_RS23070 19943..20161 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
BAT61_RS23075 20163..20468 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
BAT61_RS23080 20469..21275 + 807 WP_000016969.1 site-specific integrase -
BAT61_RS23085 21455..22099 + 645 WP_001144036.1 ParA family protein -
BAT61_RS23090 22186..22494 + 309 WP_000030199.1 hypothetical protein -
BAT61_RS23095 22908..23888 + 981 WP_000688514.1 plasmid segregation protein ParM -
BAT61_RS23100 23881..24297 + 417 WP_001278818.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101723 101723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T64754 WP_001159871.1 NZ_CP016522:20163-20468 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T64754 NZ_CP016522:20163-20468 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT64754 WP_000813630.1 NZ_CP016522:19943-20161 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT64754 NZ_CP016522:19943-20161 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References