Detailed information of TA system TA064753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 2395..2942
• Replicon: plasmid pSA02DT09004001_101
• Accession: NZ_CP016522
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg strain SA02DT09004001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BAT61_RS22965
• Protein ID: WP_000969983.1
• Coordinates: 2661..2942 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5JBQ7
• Locus tag: BAT61_RS22960
• Protein ID: WP_000079943.1
• Coordinates: 2395..2664 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAT61_RS22955	455..1486	+	1032	WP_000907873.1	replication initiation protein	-
BAT61_RS26135	2182..2340	+	159	WP_057716710.1	hypothetical protein	-
BAT61_RS22960	2395..2664	+	270	WP_000079943.1	hypothetical protein	Antitoxin
BAT61_RS22965	2661..2942	+	282	WP_000969983.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAT61_RS22970	2988..3836	+	849	WP_065612308.1	3'-5' exonuclease	-
BAT61_RS22975	3953..4426	+	474	WP_001334658.1	hypothetical protein	-
BAT61_RS22980	4903..5169	-	267	WP_000955263.1	hypothetical protein	-
BAT61_RS22985	5169..5663	-	495	WP_001459505.1	hypothetical protein	-
BAT61_RS22990	5719..6321	-	603	WP_000517695.1	hypothetical protein	-
BAT61_RS22995	6675..7559	+	885	Protein_9	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..101723	101723

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (146-196)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T64753 WP_000969983.1 NZ_CP016522:2661-2942 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T64753 NZ_CP016522:2661-2942 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 11553.68 Da
• Isoelectric Point: 12.7493

>AT64753 WP_000079943.1 NZ_CP016522:2395-2664 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Nucleotide

• Length: 270 bp

>AT64753 NZ_CP016522:2395-2664 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A622US83