Detailed information of TA system TA064748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 22277..22799
• Replicon: plasmid p11-004736-1-7_37
• Accession: NZ_CP016515
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg strain 11-004736-1-7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: BAU00_RS23095
• Protein ID: WP_000220560.1
• Coordinates: 22277..22558 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: BAU00_RS23100
• Protein ID: WP_000121743.1
• Coordinates: 22548..22799 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAU00_RS23060	18125..19291	-	1167	WP_000539532.1	relaxase/mobilization nuclease domain-containing protein	-
BAU00_RS23065	19294..19839	-	546	WP_000757693.1	hypothetical protein	-
BAU00_RS26070	19834..19908	-	75	Protein_23	DNA distortion polypeptide 3	-
BAU00_RS25085	20165..20437	-	273	WP_000160399.1	hypothetical protein	-
BAU00_RS26075	20450..20599	-	150	WP_000003880.1	hypothetical protein	-
BAU00_RS25090	20669..20848	-	180	WP_000439078.1	hypothetical protein	-
BAU00_RS23075	20891..21220	-	330	WP_000866646.1	hypothetical protein	-
BAU00_RS23080	21313..21528	-	216	WP_001180116.1	hypothetical protein	-
BAU00_RS23085	21518..21763	-	246	WP_000356547.1	hypothetical protein	-
BAU00_RS23090	21808..22131	-	324	WP_001181903.1	hypothetical protein	-
BAU00_RS23095	22277..22558	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAU00_RS23100	22548..22799	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
BAU00_RS23105	24033..24869	+	837	WP_001050931.1	replication initiation protein	-
BAU00_RS23110	24909..25355	+	447	WP_001074386.1	hypothetical protein	-
BAU00_RS23115	25423..25848	+	426	WP_000202944.1	hypothetical protein	-
BAU00_RS23120	25845..26822	-	978	WP_001269910.1	hypothetical protein	-
BAU00_RS23125	26847..27128	-	282	WP_001185482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37697	37697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (146-196)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T64748 WP_000220560.1 NZ_CP016515:c22558-22277 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T64748 NZ_CP016515:c22558-22277 [Salmonella enterica subsp. enterica serovar Heidelberg]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT64748 WP_000121743.1 NZ_CP016515:c22799-22548 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT64748 NZ_CP016515:c22799-22548 [Salmonella enterica subsp. enterica serovar Heidelberg]
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301