Detailed information of TA system TA064745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1562655..1563267
• Replicon: chromosome
• Accession: NZ_CP016501
• Organism: Streptococcus agalactiae strain WC1535

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: BBP08_RS07880
• Protein ID: WP_000384860.1
• Coordinates: 1562932..1563267 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: BBP08_RS07875
• Protein ID: WP_000259017.1
• Coordinates: 1562655..1562942 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBP08_RS07825	1557747..1558607	-	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-
BBP08_RS07845	1559450..1559731	-	282	WP_000052406.1	hypothetical protein	-
BBP08_RS07850	1559765..1560151	-	387	WP_000259069.1	hypothetical protein	-
BBP08_RS07855	1560136..1560816	-	681	WP_001865565.1	hypothetical protein	-
BBP08_RS07860	1560789..1561349	-	561	WP_001865562.1	hypothetical protein	-
BBP08_RS07865	1561349..1561756	-	408	WP_000749954.1	hypothetical protein	-
BBP08_RS07870	1561858..1562148	-	291	WP_000078283.1	WXG100 family type VII secretion target	-
BBP08_RS07875	1562655..1562942	+	288	WP_000259017.1	hypothetical protein	Antitoxin
BBP08_RS07880	1562932..1563267	+	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BBP08_RS07885	1563572..1564042	-	471	WP_000130119.1	hypothetical protein	-
BBP08_RS07890	1564210..1565466	-	1257	WP_000122836.1	plasmid recombination protein	-
BBP08_RS07895	1565783..1566217	-	435	WP_001220479.1	hypothetical protein	-
BBP08_RS07900	1566253..1567128	-	876	WP_000421240.1	hypothetical protein	-
BBP08_RS07910	1567428..1568069	-	642	WP_000591144.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1562381..1571236	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T64745 WP_000384860.1 NZ_CP016501:1562932-1563267 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T64745 NZ_CP016501:1562932-1563267 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT64745 WP_000259017.1 NZ_CP016501:1562655-1562942 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT64745 NZ_CP016501:1562655-1562942 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6