Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4163240..4163841 Replicon chromosome
Accession NZ_CP016499
Organism Agrobacterium sp. RAC06

Toxin (Protein)


Gene name hicA Uniprot ID A0A1B3NYP8
Locus tag BSY240_RS19705 Protein ID WP_069043448.1
Coordinates 4163659..4163841 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0N0JMU0
Locus tag BSY240_RS19700 Protein ID WP_054148233.1
Coordinates 4163240..4163638 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY240_RS19685 4160246..4160608 - 363 WP_054148231.1 hypothetical protein -
BSY240_RS19690 4160795..4162237 - 1443 WP_054148232.1 homospermidine synthase -
BSY240_RS19695 4162374..4163243 - 870 WP_069043447.1 DUF3445 domain-containing protein -
BSY240_RS19700 4163240..4163638 - 399 WP_054148233.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BSY240_RS19705 4163659..4163841 - 183 WP_069043448.1 type II toxin-antitoxin system HicA family toxin Toxin
BSY240_RS19710 4163898..4164182 - 285 WP_069043449.1 GTP cyclohydrolase -
BSY240_RS19715 4164191..4164811 - 621 WP_083229681.1 aminotransferase class IV family protein -
BSY240_RS19720 4164796..4165959 - 1164 WP_069043451.1 aminodeoxychorismate synthase component I -
BSY240_RS19725 4165979..4167829 - 1851 WP_069043452.1 M3 family oligoendopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6677.87 Da        Isoelectric Point: 11.0889

>T64741 WP_069043448.1 NZ_CP016499:c4163841-4163659 [Agrobacterium sp. RAC06]
MEKDSRKIIQRLKAEGYELVSVSGSHHKLRKGGKTIIVPHPKKDFPLGTARAIAKQAGWI

Download         Length: 183 bp

>T64741 NZ_CP016499:c4163841-4163659 [Agrobacterium sp. RAC06]
ATGGAGAAGGACTCGCGCAAGATCATCCAGCGCCTGAAGGCCGAGGGATATGAACTTGTTTCGGTGTCTGGCTCCCATCA
CAAGCTTCGGAAAGGTGGCAAGACGATCATCGTGCCCCATCCGAAGAAGGATTTCCCGCTTGGCACCGCCCGGGCGATTG
CGAAACAGGCGGGCTGGATCTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14631.49 Da        Isoelectric Point: 4.4008

>AT64741 WP_054148233.1 NZ_CP016499:c4163638-4163240 [Agrobacterium sp. RAC06]
MRYYVALVHKDLESAYGISFPDLPTVFSAADRDEDLVINAIEALRLWAEDEELPVPSSHQDIVERSDVRDELAAGAFLIR
VPLIEDDTRTVRANITMEAGTLAAIDQAAKQRGLTRSAFLASCARKEIERSA

Download         Length: 399 bp

>AT64741 NZ_CP016499:c4163638-4163240 [Agrobacterium sp. RAC06]
ATGCGATACTACGTGGCTTTGGTCCATAAGGACCTGGAGAGTGCCTACGGCATCAGCTTCCCCGATTTGCCAACCGTATT
CTCGGCAGCGGATCGCGATGAAGACCTTGTCATCAACGCAATCGAAGCCTTGAGGCTTTGGGCAGAGGATGAAGAGCTTC
CGGTCCCCTCCTCTCATCAGGATATCGTCGAGCGTTCCGATGTTCGTGACGAATTGGCTGCCGGCGCATTCCTCATCCGC
GTGCCCCTCATCGAAGACGATACACGGACTGTCCGGGCGAACATCACGATGGAAGCAGGAACGCTGGCCGCAATCGACCA
GGCAGCCAAGCAGCGAGGCCTCACCCGGTCGGCCTTCCTGGCAAGCTGCGCTCGCAAAGAGATCGAGCGCTCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3NYP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0N0JMU0

References