Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3155277..3156111 Replicon chromosome
Accession NZ_CP016497
Organism Escherichia coli strain UPEC 26-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag BB344_RS15410 Protein ID WP_000854689.1
Coordinates 3155734..3156111 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag BB344_RS15405 Protein ID WP_065726091.1
Coordinates 3155277..3155657 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB344_RS15370 3151557..3152012 + 456 WP_001545736.1 hypothetical protein -
BB344_RS15375 3152091..3152324 + 234 WP_001119729.1 DUF905 family protein -
BB344_RS15380 3152424..3153242 + 819 WP_001234620.1 DUF945 domain-containing protein -
BB344_RS15385 3153297..3153782 + 486 WP_000849588.1 antirestriction protein -
BB344_RS15390 3153798..3154274 + 477 WP_032186123.1 RadC family protein -
BB344_RS15395 3154343..3154564 + 222 WP_000692345.1 DUF987 domain-containing protein -
BB344_RS15400 3154583..3155227 + 645 WP_000086755.1 hypothetical protein -
BB344_RS15405 3155277..3155657 + 381 WP_065726091.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BB344_RS15410 3155734..3156111 + 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
BB344_RS15415 3156108..3156596 + 489 WP_042041996.1 hypothetical protein -
BB344_RS15420 3156608..3156805 + 198 WP_000839236.1 DUF957 domain-containing protein -
BB344_RS15425 3156919..3157737 + 819 WP_001545729.1 DUF4942 domain-containing protein -
BB344_RS15430 3157796..3157999 - 204 WP_001545728.1 hypothetical protein -
BB344_RS15435 3158009..3158659 - 651 WP_000056760.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
BB344_RS15440 3158673..3159137 - 465 WP_000776521.1 PTS ascorbate transporter subunit IIA -
BB344_RS15445 3159147..3159452 - 306 WP_000218360.1 PTS ascorbate transporter subunit IIB -
BB344_RS15450 3159468..3160865 - 1398 WP_000404886.1 PTS ascorbate transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T64719 WP_000854689.1 NZ_CP016497:3155734-3156111 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T64719 NZ_CP016497:3155734-3156111 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14001.76 Da        Isoelectric Point: 5.0823

>AT64719 WP_065726091.1 NZ_CP016497:3155277-3155657 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPTE

Download         Length: 381 bp

>AT64719 NZ_CP016497:3155277-3155657 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTACGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References