Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2646767..2647565 Replicon chromosome
Accession NZ_CP016497
Organism Escherichia coli strain UPEC 26-1

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag BB344_RS12880 Protein ID WP_000854730.1
Coordinates 2647188..2647565 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag BB344_RS12875 Protein ID WP_001285481.1
Coordinates 2646767..2647141 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB344_RS12835 2642742..2643194 + 453 WP_000682723.1 hypothetical protein -
BB344_RS12840 2643312..2643545 + 234 WP_001213776.1 DUF905 family protein -
BB344_RS12845 2643645..2644466 + 822 WP_021519083.1 DUF945 domain-containing protein -
BB344_RS12850 2644466..2644711 + 246 WP_001164966.1 hypothetical protein -
BB344_RS12855 2644805..2645278 + 474 WP_000855076.1 antirestriction protein -
BB344_RS12860 2645294..2645770 + 477 WP_001186170.1 RadC family protein -
BB344_RS12865 2645833..2646054 + 222 WP_000692315.1 DUF987 domain-containing protein -
BB344_RS12870 2646073..2646717 + 645 WP_001555333.1 hypothetical protein -
BB344_RS12875 2646767..2647141 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BB344_RS12880 2647188..2647565 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
BB344_RS27570 2647562..2648054 + 493 Protein_2473 hypothetical protein -
BB344_RS12895 2648133..2649121 - 989 Protein_2474 IS630 family transposase -
BB344_RS12900 2649269..2649457 - 189 Protein_2475 IS66 family transposase -
BB344_RS12905 2649518..2650651 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
BB344_RS12910 2650905..2652309 - 1405 Protein_2477 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T64713 WP_000854730.1 NZ_CP016497:2647188-2647565 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T64713 NZ_CP016497:2647188-2647565 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT64713 WP_001285481.1 NZ_CP016497:2646767-2647141 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT64713 NZ_CP016497:2646767-2647141 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References