Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1703951..1704752 Replicon chromosome
Accession NZ_CP016497
Organism Escherichia coli strain UPEC 26-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag BB344_RS08385 Protein ID WP_000854739.1
Coordinates 1703951..1704331 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag BB344_RS08390 Protein ID WP_001285482.1
Coordinates 1704378..1704752 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB344_RS08350 1699542..1700096 - 555 WP_001001909.1 molecular chaperone YcdY -
BB344_RS08355 1700120..1700857 - 738 WP_000283664.1 zinc-binding phosphatase -
BB344_RS08360 1700912..1701850 - 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
BB344_RS08370 1702337..1703164 - 828 WP_001304477.1 DUF4942 domain-containing protein -
BB344_RS08375 1703249..1703446 - 198 WP_000772027.1 DUF957 domain-containing protein -
BB344_RS08380 1703466..1703954 - 489 WP_001054232.1 hypothetical protein -
BB344_RS08385 1703951..1704331 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
BB344_RS08390 1704378..1704752 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BB344_RS08395 1704802..1705446 - 645 WP_000086763.1 hypothetical protein -
BB344_RS08400 1705465..1705686 - 222 WP_000692315.1 DUF987 domain-containing protein -
BB344_RS08405 1705749..1706225 - 477 WP_001186170.1 RadC family protein -
BB344_RS08410 1706241..1706714 - 474 WP_000855076.1 antirestriction protein -
BB344_RS08415 1706977..1707798 - 822 WP_001234710.1 DUF945 domain-containing protein -
BB344_RS30520 1707879..1708090 + 212 Protein_1618 hypothetical protein -
BB344_RS08425 1708209..1708664 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T64711 WP_000854739.1 NZ_CP016497:c1704331-1703951 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T64711 NZ_CP016497:c1704331-1703951 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT64711 WP_001285482.1 NZ_CP016497:c1704752-1704378 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT64711 NZ_CP016497:c1704752-1704378 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References