Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 756698..757176 Replicon chromosome
Accession NZ_CP016497
Organism Escherichia coli strain UPEC 26-1

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag BB344_RS03265 Protein ID WP_000936799.1
Coordinates 756698..756985 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag BB344_RS03270 Protein ID WP_000100899.1
Coordinates 756985..757176 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB344_RS03230 753994..754215 - 222 WP_000560231.1 cell division protein FtsZ -
BB344_RS03235 754261..755109 - 849 WP_000935606.1 Rha family phage regulatory protein -
BB344_RS03245 755677..755898 + 222 WP_000202161.1 hypothetical protein -
BB344_RS03250 755888..756262 - 375 WP_001553098.1 hypothetical protein -
BB344_RS03255 756274..756426 - 153 WP_000379609.1 DUF1391 family protein -
BB344_RS03265 756698..756985 - 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BB344_RS03270 756985..757176 - 192 WP_000100899.1 hypothetical protein Antitoxin
BB344_RS03275 757204..757605 - 402 WP_001329851.1 helix-turn-helix domain-containing protein -
BB344_RS03280 757715..757987 + 273 WP_000887447.1 helix-turn-helix domain-containing protein -
BB344_RS03285 757971..758396 + 426 WP_000693918.1 Rha family transcriptional regulator -
BB344_RS03290 758468..759538 + 1071 WP_001262355.1 hypothetical protein -
BB344_RS03295 759579..760004 + 426 WP_001151152.1 DUF977 family protein -
BB344_RS03300 760179..760844 + 666 WP_000150294.1 epoxyqueuosine reductase QueH -
BB344_RS03305 761082..761237 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BB344_RS28805 761405..761683 + 279 WP_024193993.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T64697 WP_000936799.1 NZ_CP016497:c756985-756698 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T64697 NZ_CP016497:c756985-756698 [Escherichia coli]
ATGTTACCCATTTTGTGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCTAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGGATTGAAACGTCTGTTTTAGCCCTCTCTGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAACTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT64697 WP_000100899.1 NZ_CP016497:c757176-756985 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT64697 NZ_CP016497:c757176-756985 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTACGCGC
TAAAGTGGCGTCAAGCCTTGCAGACCCTCGTCCCTCAATTCCACATGATGAGGTAATGGCTGAAATGGAGAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References