Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 81893..82473 Replicon plasmid unnamed6
Accession NZ_CP016489
Organism Synechococcus sp. PCC 8807

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AWQ24_RS15440 Protein ID WP_041444131.1
Coordinates 81893..82237 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B1U2U2
Locus tag AWQ24_RS15445 Protein ID WP_030008115.1
Coordinates 82231..82473 (-) Length 81 a.a.

Genomic Context

AWQ24_RS15420AWQ24_RS15425AWQ24_RS15430AWQ24_RS15435AWQ24_RS15440AWQ24_RS15445AWQ24_RS15450AWQ24_RS15455AWQ24_RS15460AWQ24_RS15465
Location: 77201..79786 (2586 bp)
Type: Others
Protein ID: WP_065717592.1
Location: 79912..80277 (366 bp)
Type: Others
Protein ID: WP_041444158.1
Location: 80342..81229 (888 bp)
Type: Others
Protein ID: WP_143589451.1
Location: 81294..81830 (537 bp)
Type: Others
Protein ID: WP_065717537.1
Location: 81893..82237 (345 bp)
Type: Toxin
Protein ID: WP_041444131.1
Location: 82231..82473 (243 bp)
Type: Antitoxin
Protein ID: WP_030008115.1
Location: 82578..83393 (816 bp)
Type: Others
Protein ID: WP_065717538.1
Location: 83397..84434 (1038 bp)
Type: Others
Protein ID: WP_065717539.1
Location: 84434..85405 (972 bp)
Type: Others
Protein ID: WP_065717593.1
Location: 85524..86429 (906 bp)
Type: Others
Protein ID: WP_065717540.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AWQ24_RS1542077201..79786+2586WP_065717592.1TonB-dependent hemoglobin/transferrin/lactoferrin family receptor-
AWQ24_RS1542579912..80277+366WP_041444158.1VOC family protein-
AWQ24_RS1543080342..81229+888WP_143589451.1ABC transporter substrate-binding protein-
AWQ24_RS1543581294..81830+537WP_065717537.1hypothetical protein-
AWQ24_RS1544081893..82237-345WP_041444131.1type II toxin-antitoxin system PemK/MazF family toxinToxin
AWQ24_RS1544582231..82473-243WP_030008115.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
AWQ24_RS1545082578..83393-816WP_065717538.1ABC transporter ATP-binding protein-
AWQ24_RS1545583397..84434-1038WP_065717539.1iron ABC transporter permease-
AWQ24_RS1546084434..85405-972WP_065717593.1iron ABC transporter permease-
AWQ24_RS1546585524..86429-906WP_065717540.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..165618165618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

Antitoxin PemI-like

(3-80)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12861.20 Da        Isoelectric Point: 9.1547

>T64691 WP_041444131.1 NZ_CP016489:c82237-81893 [Synechococcus sp. PCC 8807]
MVKINGMVPKRGDIIFLELNPRTGSEQSGYRPAIVISPEEYNRISNLTLICPITNKEKGWVFEVKLPPNLKTQGVILVDQ
IRAVDCRARKAKIVEQLPLDTLNEVLARLEPLLI

Download         Length: 345 bp

>T64691 NZ_CP016489:c82237-81893 [Synechococcus sp. PCC 8807]
TTGGTAAAAATTAACGGCATGGTTCCTAAGCGGGGGGATATTATTTTTCTCGAACTGAATCCCCGCACAGGTAGTGAACA
ATCAGGTTATCGTCCGGCGATCGTGATTTCTCCTGAGGAATATAACCGTATTTCTAATCTGACCCTAATCTGTCCAATCA
CGAATAAAGAAAAAGGCTGGGTGTTTGAGGTGAAACTTCCGCCTAATCTCAAAACCCAAGGCGTCATCCTGGTCGATCAA
ATCCGGGCGGTGGACTGTCGAGCCAGGAAAGCAAAAATTGTGGAACAACTTCCCCTTGACACTCTTAATGAAGTACTCGC
GAGGTTAGAGCCTCTTTTGATTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9119.28 Da        Isoelectric Point: 4.5125

>AT64691 WP_030008115.1 NZ_CP016489:c82473-82231 [Synechococcus sp. PCC 8807]
MITQKITKWGNSFGIRLPQSMLQQCGWQEGEQVTISMENNQIILSLARPKYSLAELLKDAKPEAQHSEVDWGEAQGEESW

Download         Length: 243 bp

>AT64691 NZ_CP016489:c82473-82231 [Synechococcus sp. PCC 8807]
ATGATCACCCAAAAAATCACGAAATGGGGCAACTCTTTTGGTATTCGCTTGCCTCAATCCATGCTCCAGCAATGCGGTTG
GCAGGAAGGGGAACAAGTGACGATATCAATGGAAAACAACCAAATTATTTTGAGCCTTGCTCGACCAAAATATAGCCTTG
CGGAATTACTCAAGGATGCAAAACCTGAAGCACAGCATTCTGAAGTGGACTGGGGGGAAGCCCAAGGAGAAGAGTCTTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1B1U2U2

References