Detailed information of TA system TA064690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1657564..1658162
• Replicon: chromosome
• Accession: NZ_CP016483
• Organism: Synechococcus sp. PCC 8807

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AWQ24_RS07930
• Protein ID: WP_065717338.1
• Coordinates: 1657564..1657818 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AWQ24_RS07935
• Protein ID: WP_065716486.1
• Coordinates: 1657815..1658162 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AWQ24_RS07905	1652728..1654110	-	1383	WP_030008145.1	photosystem II reaction center protein CP43	-
AWQ24_RS07910	1654094..1655152	-	1059	WP_012307174.1	photosystem II D2 protein (photosystem q(a) protein)	-
AWQ24_RS07915	1655467..1656024	-	558	WP_065716483.1	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	-
AWQ24_RS07920	1656061..1656933	-	873	WP_065716484.1	prolipoprotein diacylglyceryl transferase	-
AWQ24_RS07925	1656930..1657334	-	405	WP_065716485.1	preQ(1) synthase	-
AWQ24_RS07930	1657564..1657818	+	255	WP_065717338.1	type II toxin-antitoxin system HicA family toxin	Toxin
AWQ24_RS07935	1657815..1658162	+	348	WP_065716486.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AWQ24_RS07940	1658213..1658506	-	294	WP_062434216.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
AWQ24_RS07945	1658559..1659080	-	522	WP_065716487.1	photosystem I assembly protein Ycf3	-
AWQ24_RS07950	1659149..1660129	+	981	WP_065716488.1	DNA polymerase III subunit delta	-
AWQ24_RS07955	1660250..1660735	+	486	WP_065716489.1	DUF4168 domain-containing protein	-
AWQ24_RS07960	1660873..1661742	-	870	WP_030007031.1	M48 family metalloprotease	-
AWQ24_RS07965	1661879..1662160	-	282	WP_012307184.1	hypothetical protein	-
AWQ24_RS07970	1662387..1662671	-	285	WP_012307185.1	DUF2470 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9350.81 Da
• Isoelectric Point: 11.2132

>T64690 WP_065717338.1 NZ_CP016483:1657564-1657818 [Synechococcus sp. PCC 8807]
MKRRNSKTLALIFQRPISGNIAWSDIEALFLELGADISERSGSRVAVILFGEVRVFHRPHPSPTTDKGAVASIRKWLESH
GVKP

Nucleotide

• Length: 255 bp

>T64690 NZ_CP016483:1657564-1657818 [Synechococcus sp. PCC 8807]
ATGAAGCGTAGAAACAGTAAAACCCTAGCGCTTATTTTCCAAAGGCCCATCAGTGGCAACATTGCCTGGTCTGACATCGA
AGCACTCTTTCTGGAACTAGGAGCAGACATTTCTGAGAGGAGTGGCTCACGAGTTGCGGTGATTCTCTTTGGTGAAGTGC
GGGTTTTTCATCGACCTCACCCTTCCCCTACAACTGATAAAGGAGCCGTTGCCAGTATTCGGAAATGGTTAGAATCCCAC
GGAGTAAAGCCATGA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13202.00 Da
• Isoelectric Point: 4.7573

>AT64690 WP_065716486.1 NZ_CP016483:1657815-1658162 [Synechococcus sp. PCC 8807]
MNMMILDGYRAKIEYDPELDLFRGEILGLNGGADFYGRNPEELRQEFKNSLAVFLEVCKEKGISPIKEYSGRFNLRVSPE
LHREIAILTASKNTSINRWITEVLQEAVQSTDYAQ

Nucleotide

• Length: 348 bp

>AT64690 NZ_CP016483:1657815-1658162 [Synechococcus sp. PCC 8807]
ATGAACATGATGATTCTTGATGGTTATCGAGCAAAAATTGAGTATGACCCAGAACTTGACTTATTTCGCGGTGAAATCTT
GGGGTTAAATGGTGGCGCAGATTTCTATGGCCGCAATCCCGAAGAACTCCGCCAGGAATTTAAAAATTCCCTCGCAGTAT
TTCTCGAAGTTTGTAAGGAAAAAGGCATTAGCCCCATCAAAGAATATTCAGGACGCTTTAACCTACGAGTTTCACCAGAG
CTACACCGTGAAATCGCGATTTTGACGGCCAGCAAAAATACCAGCATCAATAGGTGGATTACCGAAGTTCTGCAAGAAGC
GGTGCAATCTACTGATTATGCCCAATAA