Detailed information of TA system TA064689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 1207674..1208085
• Replicon: chromosome
• Accession: NZ_CP016483
• Organism: Synechococcus sp. PCC 8807

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AWQ24_RS15895
• Protein ID: WP_071819463.1
• Coordinates: 1207900..1208085 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AWQ24_RS05890
• Protein ID: WP_065716255.1
• Coordinates: 1207674..1207886 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AWQ24_RS05870	1202956..1203870	-	915	WP_065716253.1	heme A synthase	-
AWQ24_RS05875	1204257..1205252	+	996	WP_062436555.1	cytochrome c oxidase subunit II	-
AWQ24_RS05880	1205337..1206983	+	1647	WP_065716254.1	cytochrome c oxidase subunit I	-
AWQ24_RS05885	1206997..1207596	+	600	WP_012306786.1	heme-copper oxidase subunit III	-
AWQ24_RS05890	1207674..1207886	-	213	WP_065716255.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AWQ24_RS15895	1207900..1208085	-	186	WP_071819463.1	type II toxin-antitoxin system HicA family toxin	Toxin
AWQ24_RS05895	1208096..1208575	-	480	WP_012306788.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
AWQ24_RS05900	1208767..1210353	+	1587	WP_065716256.1	hypothetical protein	-
AWQ24_RS05905	1210556..1211050	+	495	WP_198161533.1	hypothetical protein	-
AWQ24_RS05910	1211118..1211582	+	465	WP_065716257.1	single-stranded DNA-binding protein	-
AWQ24_RS05915	1211586..1212968	+	1383	WP_065716258.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-61)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6803.93 Da
• Isoelectric Point: 10.8214

>T64689 WP_071819463.1 NZ_CP016483:c1208085-1207900 [Synechococcus sp. PCC 8807]
MKVKEIIKLIEQDGWSLTRTRGSHRQYKHPTKLGLVTVAGKFSDELAPGTQNSILKQAGLK

Nucleotide

• Length: 186 bp

>T64689 NZ_CP016483:c1208085-1207900 [Synechococcus sp. PCC 8807]
ATGAAAGTTAAAGAAATTATCAAACTTATAGAACAAGATGGTTGGAGCCTCACTAGAACTCGCGGAAGTCACCGTCAGTA
CAAGCATCCAACTAAACTAGGATTAGTAACAGTTGCAGGAAAATTCAGCGATGAACTAGCTCCTGGAACCCAAAATAGTA
TTCTCAAACAAGCTGGTTTAAAGTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7537.46 Da
• Isoelectric Point: 3.7701

>AT64689 WP_065716255.1 NZ_CP016483:c1207886-1207674 [Synechococcus sp. PCC 8807]
MRYLIVIEKTDTGYSAYSPDLSGCVATGATEVEVTQNMQEAITFHLEGLQLEGLEIPQPSVSSAYVEIAA

Nucleotide

• Length: 213 bp

>AT64689 NZ_CP016483:c1207886-1207674 [Synechococcus sp. PCC 8807]
ATGCGCTATCTAATCGTCATCGAAAAAACCGATACGGGTTATTCAGCTTATTCTCCAGATTTATCTGGTTGTGTCGCAAC
AGGGGCAACAGAAGTTGAAGTGACGCAAAATATGCAAGAGGCGATCACCTTTCACCTTGAAGGATTGCAATTAGAAGGCT
TAGAAATTCCACAGCCTTCTGTTTCTTCTGCCTATGTTGAAATTGCAGCGTGA