Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 1207674..1208085 Replicon chromosome
Accession NZ_CP016483
Organism Synechococcus sp. PCC 8807

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AWQ24_RS15895 Protein ID WP_071819463.1
Coordinates 1207900..1208085 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AWQ24_RS05890 Protein ID WP_065716255.1
Coordinates 1207674..1207886 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ24_RS05870 1202956..1203870 - 915 WP_065716253.1 heme A synthase -
AWQ24_RS05875 1204257..1205252 + 996 WP_062436555.1 cytochrome c oxidase subunit II -
AWQ24_RS05880 1205337..1206983 + 1647 WP_065716254.1 cytochrome c oxidase subunit I -
AWQ24_RS05885 1206997..1207596 + 600 WP_012306786.1 heme-copper oxidase subunit III -
AWQ24_RS05890 1207674..1207886 - 213 WP_065716255.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AWQ24_RS15895 1207900..1208085 - 186 WP_071819463.1 type II toxin-antitoxin system HicA family toxin Toxin
AWQ24_RS05895 1208096..1208575 - 480 WP_012306788.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
AWQ24_RS05900 1208767..1210353 + 1587 WP_065716256.1 hypothetical protein -
AWQ24_RS05905 1210556..1211050 + 495 WP_198161533.1 hypothetical protein -
AWQ24_RS05910 1211118..1211582 + 465 WP_065716257.1 single-stranded DNA-binding protein -
AWQ24_RS05915 1211586..1212968 + 1383 WP_065716258.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-61)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6803.93 Da        Isoelectric Point: 10.8214

>T64689 WP_071819463.1 NZ_CP016483:c1208085-1207900 [Synechococcus sp. PCC 8807]
MKVKEIIKLIEQDGWSLTRTRGSHRQYKHPTKLGLVTVAGKFSDELAPGTQNSILKQAGLK

Download         Length: 186 bp

>T64689 NZ_CP016483:c1208085-1207900 [Synechococcus sp. PCC 8807]
ATGAAAGTTAAAGAAATTATCAAACTTATAGAACAAGATGGTTGGAGCCTCACTAGAACTCGCGGAAGTCACCGTCAGTA
CAAGCATCCAACTAAACTAGGATTAGTAACAGTTGCAGGAAAATTCAGCGATGAACTAGCTCCTGGAACCCAAAATAGTA
TTCTCAAACAAGCTGGTTTAAAGTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7537.46 Da        Isoelectric Point: 3.7701

>AT64689 WP_065716255.1 NZ_CP016483:c1207886-1207674 [Synechococcus sp. PCC 8807]
MRYLIVIEKTDTGYSAYSPDLSGCVATGATEVEVTQNMQEAITFHLEGLQLEGLEIPQPSVSSAYVEIAA

Download         Length: 213 bp

>AT64689 NZ_CP016483:c1207886-1207674 [Synechococcus sp. PCC 8807]
ATGCGCTATCTAATCGTCATCGAAAAAACCGATACGGGTTATTCAGCTTATTCTCCAGATTTATCTGGTTGTGTCGCAAC
AGGGGCAACAGAAGTTGAAGTGACGCAAAATATGCAAGAGGCGATCACCTTTCACCTTGAAGGATTGCAATTAGAAGGCT
TAGAAATTCCACAGCCTTCTGTTTCTTCTGCCTATGTTGAAATTGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References