Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TacT2-ataR/DUF1778(antitoxin)
Location 2568453..2569261 Replicon chromosome
Accession NZ_CP016477
Organism Synechococcus sp. PCC 7117

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1B1U0U4
Locus tag AWQ22_RS12355 Protein ID WP_065711277.1
Coordinates 2568761..2569261 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A1B1U0P4
Locus tag AWQ22_RS12350 Protein ID WP_065711276.1
Coordinates 2568453..2568752 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ22_RS12330 2563867..2566476 - 2610 WP_065711273.1 TIGR03960 family B12-binding radical SAM protein -
AWQ22_RS12335 2566548..2566940 - 393 WP_198166499.1 STAS domain-containing protein -
AWQ22_RS12340 2567357..2567545 + 189 WP_198158658.1 hypothetical protein -
AWQ22_RS12345 2567560..2568225 - 666 WP_065711275.1 endonuclease III -
AWQ22_RS12350 2568453..2568752 + 300 WP_065711276.1 DUF1778 domain-containing protein Antitoxin
AWQ22_RS12355 2568761..2569261 + 501 WP_065711277.1 GNAT family N-acetyltransferase Toxin
AWQ22_RS12360 2569351..2571492 + 2142 WP_065711278.1 glycine--tRNA ligase subunit beta -
AWQ22_RS12365 2571723..2572034 + 312 WP_012308053.1 co-chaperone GroES -
AWQ22_RS12370 2572118..2573743 + 1626 WP_012308054.1 chaperonin GroEL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-142)

Antitoxin

Vibrio phage ICP1, Orf50

(14-99)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18143.99 Da        Isoelectric Point: 9.8665

>T64687 WP_065711277.1 NZ_CP016477:2568761-2569261 [Synechococcus sp. PCC 7117]
MISAPQKLNENHDIQSFQSGEVSLDKWLKQRAHRNEQSGASRTYVICVQNRVIGYYCLANGAIAAQVATGKTRRNMPNSI
PVMVIGRLAIDQAWQGQGLGKALLRDGILRILQAAEIAGIRAILVHALSPGAKQFYEGCGFMPSPLEPMTLMITIADARN
ALESNR

Download         Length: 501 bp

>T64687 NZ_CP016477:2568761-2569261 [Synechococcus sp. PCC 7117]
ATGATCTCGGCACCGCAAAAGTTAAATGAGAATCATGATATTCAGTCTTTTCAGTCTGGTGAAGTTTCGTTGGATAAGTG
GCTAAAACAGCGGGCACACAGAAATGAGCAAAGTGGCGCCTCAAGAACTTACGTTATCTGTGTCCAAAATCGGGTGATTG
GTTACTATTGTCTCGCGAACGGGGCGATCGCCGCCCAGGTTGCTACCGGAAAAACCCGTCGGAACATGCCCAATTCGATT
CCTGTGATGGTAATTGGTCGCCTCGCTATTGATCAGGCTTGGCAAGGGCAGGGATTAGGAAAAGCGCTATTACGGGATGG
CATTTTGCGCATTTTACAAGCCGCAGAAATTGCCGGGATCCGAGCGATTCTTGTCCATGCTCTTTCCCCTGGGGCCAAAC
AATTTTACGAGGGTTGCGGTTTTATGCCGTCTCCCTTGGAACCGATGACTCTGATGATTACGATCGCCGATGCCCGCAAC
GCCCTAGAATCAAATCGGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11367.77 Da        Isoelectric Point: 5.0333

>AT64687 WP_065711276.1 NZ_CP016477:2568453-2568752 [Synechococcus sp. PCC 7117]
MSNTLLEENQATYSRNIKINIRAQQNQRDLIDRAAQVQGKSRSDFMLESACQKAQEVLLDQVFFTLDNQKYQHFLDCLDA
QPSPNNQLATLLAKPAPWE

Download         Length: 300 bp

>AT64687 NZ_CP016477:2568453-2568752 [Synechococcus sp. PCC 7117]
ATGAGTAATACTTTGCTTGAAGAGAACCAAGCCACATATTCTCGGAACATTAAAATCAATATCAGAGCACAGCAAAATCA
GCGAGATCTCATTGATCGAGCGGCTCAAGTGCAGGGCAAGAGTCGGTCAGATTTTATGCTGGAATCTGCTTGTCAAAAGG
CACAAGAGGTTTTGCTAGATCAGGTATTTTTTACGCTAGATAATCAAAAGTACCAGCATTTTTTGGATTGTCTTGATGCC
CAACCCTCACCAAATAATCAGTTAGCGACACTCCTGGCGAAGCCAGCACCCTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1U0U4

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1U0P4

References