Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 2341654..2342297 Replicon chromosome
Accession NZ_CP016477
Organism Synechococcus sp. PCC 7117

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1U088
Locus tag AWQ22_RS11310 Protein ID WP_065711141.1
Coordinates 2341896..2342297 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1U059
Locus tag AWQ22_RS11305 Protein ID WP_065711140.1
Coordinates 2341654..2341893 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ22_RS11280 2337426..2337743 - 318 WP_012307841.1 DUF1825 family protein -
AWQ22_RS11285 2337866..2338258 + 393 WP_030007317.1 SHOCT domain-containing protein -
AWQ22_RS11290 2338348..2339889 + 1542 WP_065711138.1 type I restriction-modification system subunit M -
AWQ22_RS11295 2339886..2341067 + 1182 WP_198166488.1 restriction endonuclease subunit S -
AWQ22_RS11300 2341140..2341508 + 369 WP_065711139.1 DUF559 domain-containing protein -
AWQ22_RS11305 2341654..2341893 + 240 WP_065711140.1 twitching motility protein PilT Antitoxin
AWQ22_RS11310 2341896..2342297 + 402 WP_065711141.1 type II toxin-antitoxin system VapC family toxin Toxin
AWQ22_RS16960 2342334..2343896 + 1563 WP_198166489.1 HsdR family type I site-specific deoxyribonuclease -
AWQ22_RS16965 2343923..2345431 + 1509 WP_198166490.1 type I restriction endonuclease subunit R -
AWQ22_RS11320 2345433..2346536 - 1104 WP_065711142.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AWQ22_RS11330 2347049..2347279 + 231 WP_030007319.1 DUF2811 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14790.16 Da        Isoelectric Point: 5.1799

>T64686 WP_065711141.1 NZ_CP016477:2341896-2342297 [Synechococcus sp. PCC 7117]
MTYLYLLDTNIISDLVKHPSGKIAQRIAEVGEAKICTNIVVAAELRFGAEKSGSLRLKQQVNQILEVMPVLPLESPVEFY
YAEIRTYLEREGIPIGANDLLIAAHGLALNLTVVTANQREFSRVPNLAVENWL

Download         Length: 402 bp

>T64686 NZ_CP016477:2341896-2342297 [Synechococcus sp. PCC 7117]
ATGACCTATCTCTATCTGTTGGATACAAATATCATTTCAGATTTGGTCAAGCATCCATCTGGAAAAATCGCCCAACGCAT
TGCCGAAGTTGGCGAGGCGAAGATCTGCACAAATATCGTTGTTGCCGCAGAGTTACGGTTTGGCGCAGAAAAAAGTGGAT
CACTCCGTTTAAAACAACAAGTCAATCAAATCCTTGAAGTGATGCCCGTTTTGCCCCTTGAGTCACCCGTTGAATTTTAT
TACGCCGAGATTCGCACCTATTTAGAAAGGGAAGGAATACCAATTGGTGCAAATGATTTACTGATTGCAGCCCATGGGTT
GGCTTTGAATTTAACCGTGGTTACCGCAAATCAACGTGAATTTTCGCGTGTGCCAAATTTGGCTGTGGAAAATTGGCTCT
GA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9130.46 Da        Isoelectric Point: 4.3046

>AT64686 WP_065711140.1 NZ_CP016477:2341654-2341893 [Synechococcus sp. PCC 7117]
MINQYQVRLFHNGRNQTLNIPHAFEMPSDDVVIRKEGEKLIIEPCKKKSLLELLATLPDIDEDFPDIDQGLPPLDDIQF

Download         Length: 240 bp

>AT64686 NZ_CP016477:2341654-2341893 [Synechococcus sp. PCC 7117]
ATGATTAATCAATATCAAGTCCGTTTATTTCACAATGGACGCAATCAAACCCTAAACATTCCCCACGCCTTTGAAATGCC
GAGTGATGATGTGGTCATTCGCAAAGAAGGCGAGAAATTGATTATTGAACCTTGTAAGAAAAAGTCCTTATTAGAATTGT
TGGCGACCCTGCCAGACATTGATGAAGACTTTCCAGATATTGATCAAGGCTTACCGCCCCTTGATGATATTCAATTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1U088

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1U059

References