Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 105059..105694 Replicon plasmid unnamed2
Accession NZ_CP016476
Organism Synechococcus sp. PCC 7003

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1TU41
Locus tag AWQ21_RS15125 Protein ID WP_065715524.1
Coordinates 105059..105454 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1TU14
Locus tag AWQ21_RS15130 Protein ID WP_065715525.1
Coordinates 105455..105694 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ21_RS15095 100074..102917 + 2844 WP_065715519.1 DUF1156 domain-containing protein -
AWQ21_RS16325 103224..103511 - 288 WP_157094810.1 hypothetical protein -
AWQ21_RS15105 103551..103937 + 387 WP_065715521.1 helix-turn-helix domain-containing protein -
AWQ21_RS15110 104008..104343 + 336 WP_065715636.1 XisI protein -
AWQ21_RS15115 104394..104654 + 261 WP_065715522.1 CopG family transcriptional regulator -
AWQ21_RS15120 104641..105057 + 417 WP_065715523.1 PIN domain-containing protein -
AWQ21_RS15125 105059..105454 - 396 WP_065715524.1 type II toxin-antitoxin system VapC family toxin Toxin
AWQ21_RS15130 105455..105694 - 240 WP_065715525.1 antitoxin Antitoxin
AWQ21_RS15135 105744..109061 + 3318 WP_065715526.1 DEAD/DEAH box helicase family protein -
AWQ21_RS15140 109226..109681 + 456 WP_065715527.1 hypothetical protein -
AWQ21_RS15145 109793..110620 - 828 WP_065715528.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..253256 253256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(10-54)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15030.36 Da        Isoelectric Point: 5.5506

>T64684 WP_065715524.1 NZ_CP016476:c105454-105059 [Synechococcus sp. PCC 7003]
MFLLDTNICIYIIKEKPPQVLEKFEQIEPHKLGISIITLAELEYGAAKSMNPAKNYQVIEDFIAYLDVFDWDRQASHIYG
ELRAHLNHQGTPIGILDTQIAAHCLGLNRILVTNNVREFERVPGLKVENWV

Download         Length: 396 bp

>T64684 NZ_CP016476:c105454-105059 [Synechococcus sp. PCC 7003]
ATGTTTTTGTTGGATACAAATATTTGTATTTACATCATCAAAGAAAAGCCGCCTCAAGTTTTAGAAAAGTTTGAACAAAT
TGAGCCCCACAAATTAGGGATCTCGATTATTACTCTAGCGGAATTAGAGTATGGGGCGGCAAAATCAATGAATCCTGCTA
AAAACTATCAGGTTATTGAAGATTTTATCGCTTATTTAGATGTCTTTGACTGGGATCGTCAAGCCAGTCATATTTATGGT
GAACTTCGAGCACATCTAAATCACCAGGGCACGCCTATCGGCATTTTAGATACCCAAATTGCGGCCCATTGCCTAGGCTT
AAATCGTATTTTGGTGACGAATAACGTGCGGGAGTTTGAGCGGGTTCCGGGCTTAAAGGTAGAAAATTGGGTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9399.63 Da        Isoelectric Point: 6.3247

>AT64684 WP_065715525.1 NZ_CP016476:c105694-105455 [Synechococcus sp. PCC 7003]
MAQPKTAKLFMNGNSQAVRLPREFRFEGKEVFIYKEGDRVILSPKRRSWRDFFDNAPCATPDFMETRDDQPPQEREDLF

Download         Length: 240 bp

>AT64684 NZ_CP016476:c105694-105455 [Synechococcus sp. PCC 7003]
ATGGCTCAACCTAAAACGGCAAAGTTATTTATGAATGGCAACAGTCAGGCGGTACGGTTGCCTCGTGAGTTTCGGTTTGA
GGGGAAGGAAGTTTTTATTTATAAAGAAGGCGATCGCGTAATTTTGTCTCCGAAACGGCGATCTTGGCGAGATTTTTTTG
ACAATGCTCCTTGTGCCACGCCAGATTTTATGGAAACACGGGATGACCAGCCGCCCCAAGAGCGGGAGGACTTATTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1TU41

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1TU14

References