Detailed information of TA system TA064683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2801515..2802094
• Replicon: chromosome
• Accession: NZ_CP016474
• Organism: Synechococcus sp. PCC 7003

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1B1TSB7
• Locus tag: AWQ21_RS13300
• Protein ID: WP_065714953.1
• Coordinates: 2801747..2802094 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1B1TSH4
• Locus tag: AWQ21_RS13295
• Protein ID: WP_065714952.1
• Coordinates: 2801515..2801757 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AWQ21_RS13255	2797854..2798222	+	369	WP_065714945.1	hypothetical protein	-
AWQ21_RS13260	2798297..2798764	-	468	WP_065714946.1	GNAT family N-acetyltransferase	-
AWQ21_RS13265	2798915..2799121	+	207	WP_065714947.1	prevent-host-death protein	-
AWQ21_RS15945	2799111..2799365	+	255	Protein_2642	Txe/YoeB family addiction module toxin	-
AWQ21_RS13275	2799507..2800118	+	612	WP_065714949.1	Uma2 family endonuclease	-
AWQ21_RS13280	2800173..2800493	+	321	WP_065715360.1	nucleotidyltransferase family protein	-
AWQ21_RS13285	2800483..2800827	+	345	WP_065714950.1	DUF86 domain-containing protein	-
AWQ21_RS13290	2800843..2801496	+	654	WP_065714951.1	hypothetical protein	-
AWQ21_RS13295	2801515..2801757	+	243	WP_065714952.1	hypothetical protein	Antitoxin
AWQ21_RS13300	2801747..2802094	+	348	WP_065714953.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AWQ21_RS13305	2802208..2803008	-	801	WP_065714954.1	ABC transporter permease	-
AWQ21_RS13310	2803196..2804062	+	867	WP_065714955.1	nucleotide exchange factor GrpE	-
AWQ21_RS13315	2804075..2804533	-	459	WP_065714956.1	SRPBCC family protein	-
AWQ21_RS13320	2804618..2805817	-	1200	WP_065714957.1	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminal domain	-
AWQ21_RS13325	2805944..2806156	+	213	WP_157094769.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (17-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13208.35 Da
• Isoelectric Point: 10.4894

>T64683 WP_065714953.1 NZ_CP016474:2801747-2802094 [Synechococcus sp. PCC 7003]
MPNKTPIQVETSAVFRRNLRKLAKKYRNIKKDIQPIIEALSQGKLPGDQIPGVNYPVFKLRVRNTDVQKGKSGGYRLIYY
LKTDTGIILLTLYTKSERANIAPEDIRQIIEDYSN

Nucleotide

• Length: 348 bp

>T64683 NZ_CP016474:2801747-2802094 [Synechococcus sp. PCC 7003]
ATGCCGAATAAAACCCCCATCCAAGTTGAAACGTCGGCTGTTTTTCGCCGCAATCTCCGTAAACTCGCAAAGAAATATCG
CAATATTAAAAAAGACATTCAGCCGATTATCGAAGCCCTCAGCCAAGGCAAGTTGCCAGGTGATCAAATTCCCGGCGTGA
ACTATCCTGTTTTTAAACTCAGAGTCCGCAATACTGATGTTCAAAAAGGGAAAAGTGGCGGTTATCGCTTAATCTATTAC
CTCAAGACTGATACAGGCATTATTCTACTGACGCTGTACACAAAATCTGAAAGAGCGAATATTGCGCCTGAAGATATCCG
CCAAATTATAGAAGACTATTCAAATTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9054.18 Da
• Isoelectric Point: 3.9432

>AT64683 WP_065714952.1 NZ_CP016474:2801515-2801757 [Synechococcus sp. PCC 7003]
MKAQKVMATIDAQGQLTLDNPLVAIKNSRVEVIILIPEEDEADEPTKAELLDDFRQAWHEAMTGQTLPVEQLWDEIDHAE

Nucleotide

• Length: 243 bp

>AT64683 NZ_CP016474:2801515-2801757 [Synechococcus sp. PCC 7003]
ATGAAAGCGCAAAAAGTCATGGCAACCATTGACGCTCAGGGGCAACTTACCCTTGATAACCCTTTAGTTGCGATTAAAAA
TAGTCGTGTCGAAGTCATTATCCTAATTCCTGAAGAAGACGAAGCCGATGAACCAACAAAAGCAGAATTACTCGATGACT
TTCGGCAAGCATGGCATGAAGCAATGACCGGACAAACCCTTCCCGTTGAGCAACTTTGGGATGAGATTGATCATGCCGAA
TAA

Structures

Toxin

• AlphaFold DB: A0A1B1TSB7

Antitoxin

• AlphaFold DB: A0A1B1TSH4