Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 1256430..1257007 Replicon chromosome
Accession NZ_CP016474
Organism Synechococcus sp. PCC 7003

Toxin (Protein)


Gene name mazF Uniprot ID A0A1B1TNN8
Locus tag AWQ21_RS06020 Protein ID WP_065713750.1
Coordinates 1256430..1256690 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B1TNQ6
Locus tag AWQ21_RS06025 Protein ID WP_065713751.1
Coordinates 1256678..1257007 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ21_RS06000 1251601..1253100 - 1500 WP_065713747.1 AAA family ATPase -
AWQ21_RS06005 1253203..1253541 - 339 WP_065713748.1 hypothetical protein -
AWQ21_RS06010 1253820..1255088 + 1269 WP_065715243.1 FIST C-terminal domain-containing protein -
AWQ21_RS06015 1255101..1256291 - 1191 WP_065713749.1 class I SAM-dependent rRNA methyltransferase -
AWQ21_RS06020 1256430..1256690 + 261 WP_065713750.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
AWQ21_RS06025 1256678..1257007 + 330 WP_065713751.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
AWQ21_RS06030 1257326..1258768 + 1443 WP_065713752.1 sodium:glutamate symporter -
AWQ21_RS06035 1258777..1259514 - 738 WP_157094706.1 hypothetical protein -
AWQ21_RS15880 1259830..1259922 - 93 Protein_1207 AAA family ATPase -
AWQ21_RS06040 1260029..1260772 - 744 WP_065713754.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
AWQ21_RS06045 1260769..1260999 - 231 WP_065713755.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(10-51)

Antitoxin

mRNA interferase PemK-like

(6-107)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9851.02 Da        Isoelectric Point: 4.4550

>T64679 WP_065713750.1 NZ_CP016474:1256430-1256690 [Synechococcus sp. PCC 7003]
MGAVIRTRIVKIGNSQGIRIPKLLLEQSGIDTEVEIEVQGDHLTIRTASRSRPGWDEAFSTMAQRQDDVLLDDINATNWD
RTEWEW

Download         Length: 261 bp

>T64679 NZ_CP016474:1256430-1256690 [Synechococcus sp. PCC 7003]
ATGGGCGCAGTAATCAGAACCCGCATCGTGAAAATCGGGAACTCCCAAGGCATTCGCATTCCTAAGCTACTTTTGGAACA
AAGTGGCATTGATACAGAAGTTGAAATCGAAGTGCAAGGCGATCATCTAACCATTCGCACCGCCTCCCGCTCACGCCCAG
GCTGGGATGAAGCCTTCTCGACCATGGCCCAGCGACAGGATGATGTTCTGCTGGATGACATCAACGCTACCAATTGGGAT
CGAACAGAATGGGAATGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12246.42 Da        Isoelectric Point: 9.2313

>AT64679 WP_065713751.1 NZ_CP016474:1256678-1257007 [Synechococcus sp. PCC 7003]
MGMVAKRFDVFLVNLDPTIGSEIQKTRPCVIISPDEMNRHIATVIVAPMTTKGKAYPTRVICQFQGKSGQIVLDQIRTID
KSRLVKKLGQISQDEQRIVLETLAEMFAE

Download         Length: 330 bp

>AT64679 NZ_CP016474:1256678-1257007 [Synechococcus sp. PCC 7003]
ATGGGAATGGTAGCCAAACGTTTCGATGTTTTTTTGGTGAATCTTGACCCCACTATCGGTAGTGAAATCCAAAAGACACG
CCCCTGTGTGATCATTTCACCGGATGAAATGAACCGTCATATTGCGACGGTAATTGTTGCACCGATGACAACGAAAGGAA
AAGCCTATCCAACCCGTGTTATCTGTCAGTTTCAGGGTAAAAGTGGGCAAATTGTTCTCGATCAAATTCGCACGATCGAT
AAATCTCGACTCGTCAAAAAGCTGGGTCAAATTAGTCAAGATGAACAAAGAATAGTGCTTGAAACTTTGGCAGAGATGTT
TGCTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1TNN8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1TNQ6

References