Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4592327..4592925 Replicon chromosome
Accession NZ_CP016464
Organism Bosea sp. RAC05

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B3NI48
Locus tag BSY19_RS25245 Protein ID WP_069056569.1
Coordinates 4592327..4592716 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B3NKX5
Locus tag BSY19_RS25250 Protein ID WP_069056570.1
Coordinates 4592713..4592925 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY19_RS25220 4587445..4588338 - 894 WP_083247826.1 manganese/iron ABC transporter ATP-binding protein -
BSY19_RS25225 4588368..4589276 - 909 WP_069056565.1 metal ABC transporter substrate-binding protein -
BSY19_RS25230 4589403..4589852 + 450 WP_069056566.1 transcriptional repressor -
BSY19_RS25235 4589859..4591442 - 1584 WP_069056567.1 glucan biosynthesis protein G -
BSY19_RS25240 4591756..4592319 + 564 WP_069056568.1 VOC family protein -
BSY19_RS25245 4592327..4592716 - 390 WP_069056569.1 PIN domain-containing protein Toxin
BSY19_RS25250 4592713..4592925 - 213 WP_069056570.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BSY19_RS25255 4593491..4594636 + 1146 WP_069056571.1 type III PLP-dependent enzyme -
BSY19_RS25260 4594865..4595401 + 537 WP_069056572.1 N-acetyltransferase -
BSY19_RS25265 4595512..4596447 + 936 WP_083247828.1 sugar ABC transporter permease -
BSY19_RS25270 4596444..4597298 + 855 WP_069056573.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-41)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14367.89 Da        Isoelectric Point: 10.3511

>T64676 WP_069056569.1 NZ_CP016464:c4592716-4592327 [Bosea sp. RAC05]
MIVVDSSVWIAQLRAQSSPAVAALSGMPSPTRIIVGDLVLMELLRGARDERHAESLERAMRRFRIEPMVDVALALAAARH
SRFLRGRGVTIRKTIDLLIATFCIERGHALLHQDRDFDLIAQYLPLAIA

Download         Length: 390 bp

>T64676 NZ_CP016464:c4592716-4592327 [Bosea sp. RAC05]
ATGATTGTGGTCGACAGCTCTGTCTGGATCGCACAGCTGCGTGCGCAAAGCAGTCCAGCCGTCGCCGCGCTGTCAGGGAT
GCCGTCGCCGACGCGGATCATCGTTGGCGATCTGGTCCTGATGGAGCTTCTGCGCGGCGCCCGCGACGAGCGCCACGCCG
AAAGTCTCGAGCGGGCGATGCGCCGCTTCAGGATCGAGCCGATGGTCGATGTGGCGCTCGCGCTGGCCGCCGCCCGGCAT
TCGCGCTTTCTGAGGGGGCGGGGAGTGACCATCCGCAAGACGATCGATCTCCTGATCGCCACCTTTTGCATCGAACGCGG
CCATGCCCTGCTCCATCAGGACCGGGATTTCGACCTGATCGCGCAGTACTTGCCATTGGCCATCGCCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7939.05 Da        Isoelectric Point: 4.6182

>AT64676 WP_069056570.1 NZ_CP016464:c4592925-4592713 [Bosea sp. RAC05]
MRTNIDIDDALLKEAMEVTGLPTKKATVEEALRRLVKNAELRQVISDMRGLGWEGDLDEMRTDRPADPRS

Download         Length: 213 bp

>AT64676 NZ_CP016464:c4592925-4592713 [Bosea sp. RAC05]
ATGCGCACGAATATCGACATCGACGACGCGCTTCTCAAGGAGGCGATGGAGGTGACGGGGCTGCCGACCAAGAAGGCGAC
CGTCGAGGAGGCGCTGCGCCGACTCGTCAAGAACGCCGAACTGCGCCAGGTGATCAGCGACATGCGCGGTCTGGGGTGGG
AGGGCGATCTCGACGAGATGCGCACGGACAGGCCCGCCGACCCTCGCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3NI48

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3NKX5

References