Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 4420238..4420790 Replicon chromosome
Accession NZ_CP016464
Organism Bosea sp. RAC05

Toxin (Protein)


Gene name parE Uniprot ID A0A1B3NPP9
Locus tag BSY19_RS24475 Protein ID WP_069056440.1
Coordinates 4420500..4420790 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B3NLK5
Locus tag BSY19_RS24470 Protein ID WP_069056439.1
Coordinates 4420238..4420507 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY19_RS24440 4415609..4415911 + 303 WP_069056433.1 hypothetical protein -
BSY19_RS24445 4416018..4416665 - 648 WP_069056434.1 hypothetical protein -
BSY19_RS24450 4416918..4417130 + 213 WP_069056435.1 hypothetical protein -
BSY19_RS24455 4417286..4417606 + 321 WP_069056436.1 polyhydroxyalkanoic acid system family protein -
BSY19_RS24460 4417769..4419523 + 1755 WP_069056437.1 Kef family K(+) transporter -
BSY19_RS24465 4419693..4420106 - 414 WP_069056438.1 DUF3830 family protein -
BSY19_RS24470 4420238..4420507 + 270 WP_069056439.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BSY19_RS24475 4420500..4420790 + 291 WP_069056440.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSY19_RS24480 4420804..4421874 - 1071 WP_069056441.1 patatin-like phospholipase family protein -
BSY19_RS24485 4421871..4422656 - 786 WP_069056442.1 3-hydroxybutyrate dehydrogenase -
BSY19_RS24490 4422794..4423327 + 534 WP_069057367.1 transcriptional repressor -
BSY19_RS24495 4423356..4424630 + 1275 WP_069056443.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-89)

Antitoxin

Antitoxin ParD

(1-83)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10938.60 Da        Isoelectric Point: 6.7601

>T64675 WP_069056440.1 NZ_CP016464:4420500-4420790 [Bosea sp. RAC05]
MAEFVLTKRAEADLYDLALFGLERFGERQVEAYLAELDHVFSLLADHPRMGRRAEAIAPGVRRHEHRAHVILYEEMQTGV
RILAVIHGSSLSRLTL

Download         Length: 291 bp

>T64675 NZ_CP016464:4420500-4420790 [Bosea sp. RAC05]
ATGGCTGAATTCGTCCTGACGAAACGAGCGGAGGCCGATCTCTACGACCTCGCCCTGTTCGGCCTGGAACGGTTCGGCGA
ACGACAGGTCGAAGCCTATCTCGCCGAACTCGATCACGTCTTCAGCCTGCTGGCTGACCATCCACGCATGGGCCGCCGGG
CTGAGGCGATCGCGCCAGGTGTGCGGCGCCACGAGCATCGCGCGCACGTCATCCTCTATGAAGAGATGCAGACTGGCGTC
CGGATCCTCGCCGTCATTCACGGCAGCAGCCTGAGCAGACTGACGCTGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9939.20 Da        Isoelectric Point: 8.5841

>AT64675 WP_069056439.1 NZ_CP016464:4420238-4420507 [Bosea sp. RAC05]
MATMTISLPDPMKEWIEAQIRQGEYASTSDYVRDLVRRDRERRAHPELTLADLQRIVAESRASGTSDKTLPDILAQAKRA
AEGKAGRNG

Download         Length: 270 bp

>AT64675 NZ_CP016464:4420238-4420507 [Bosea sp. RAC05]
ATGGCGACAATGACGATTTCCTTGCCCGATCCGATGAAGGAATGGATCGAGGCCCAGATCAGGCAGGGCGAATATGCCAG
CACCAGCGACTATGTGCGCGACCTCGTCAGGCGGGATCGCGAGCGACGCGCCCACCCCGAACTGACCCTGGCCGATCTCC
AGCGCATCGTGGCGGAATCGCGTGCCAGCGGCACCAGCGACAAGACACTGCCGGACATTCTGGCGCAGGCGAAACGCGCG
GCGGAGGGCAAGGCCGGCCGCAATGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3NPP9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3NLK5

References