Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3945095..3945636 Replicon chromosome
Accession NZ_CP016464
Organism Bosea sp. RAC05

Toxin (Protein)


Gene name parE Uniprot ID A0A1B3NJV5
Locus tag BSY19_RS22175 Protein ID WP_069056050.1
Coordinates 3945343..3945636 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B3NE17
Locus tag BSY19_RS22170 Protein ID WP_069056049.1
Coordinates 3945095..3945346 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY19_RS22140 3940116..3940967 + 852 WP_069056044.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
BSY19_RS22145 3940995..3941600 + 606 WP_069056045.1 glutathione S-transferase -
BSY19_RS22150 3941754..3942410 - 657 WP_069056046.1 porin family protein -
BSY19_RS22155 3942606..3943589 + 984 WP_083247771.1 glycosyltransferase family 2 protein -
BSY19_RS22160 3943582..3944328 + 747 WP_069056047.1 SDR family oxidoreductase -
BSY19_RS22165 3944338..3944967 - 630 WP_069056048.1 2-hydroxychromene-2-carboxylate isomerase -
BSY19_RS22170 3945095..3945346 + 252 WP_069056049.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BSY19_RS22175 3945343..3945636 + 294 WP_069056050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSY19_RS22180 3945644..3946408 - 765 WP_069056051.1 peptidoglycan editing factor PgeF -
BSY19_RS22185 3946445..3947542 - 1098 WP_069056052.1 class I SAM-dependent methyltransferase -
BSY19_RS22190 3947539..3948387 - 849 WP_069056053.1 prolipoprotein diacylglyceryl transferase -
BSY19_RS22195 3948466..3949491 - 1026 WP_069056054.1 NADP-dependent oxidoreductase -
BSY19_RS22200 3949587..3950195 - 609 WP_083247772.1 chloramphenicol phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

Antitoxin ParD

(1-74)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10966.58 Da        Isoelectric Point: 11.7617

>T64674 WP_069056050.1 NZ_CP016464:3945343-3945636 [Bosea sp. RAC05]
MRTLFLRAAAKSDLRQISRQSRERWGAAQAFSYISGITTSLSRLPQMPELGVGRSDLGSGYRRLGVGAHVIFYRVEHDRI
EVIRILHQRMDAGSHLS

Download         Length: 294 bp

>T64674 NZ_CP016464:3945343-3945636 [Bosea sp. RAC05]
ATGAGAACGCTCTTTCTCAGGGCGGCGGCGAAGTCAGATCTTCGGCAGATCAGCCGCCAATCGAGAGAACGCTGGGGTGC
CGCGCAGGCCTTCAGCTATATCTCGGGCATCACCACTTCACTGTCCCGCCTCCCCCAAATGCCCGAACTGGGAGTGGGGC
GTTCAGATCTGGGCTCGGGCTACCGGCGCCTTGGCGTCGGCGCCCATGTCATCTTCTATCGGGTCGAGCACGACCGCATT
GAGGTCATTCGCATCCTGCACCAGCGCATGGATGCAGGCTCCCATCTGTCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8916.84 Da        Isoelectric Point: 4.0584

>AT64674 WP_069056049.1 NZ_CP016464:3945095-3945346 [Bosea sp. RAC05]
MGKNTSISLSDHFVSFIEAEVEKGRYGSASEVVRAGLRLLEDQEARIAALRAALDEGEASGEAEAFDVDAFLTEEFPDIA
PAK

Download         Length: 252 bp

>AT64674 NZ_CP016464:3945095-3945346 [Bosea sp. RAC05]
ATGGGCAAGAACACCTCGATCAGCCTCAGCGACCATTTCGTCAGCTTCATCGAAGCGGAGGTCGAGAAAGGACGCTATGG
CTCCGCCAGCGAAGTGGTGCGGGCTGGCTTGCGCCTGCTTGAAGATCAGGAGGCCCGGATCGCCGCGCTACGCGCCGCGC
TCGACGAGGGCGAAGCCAGTGGCGAAGCAGAAGCATTCGATGTCGATGCCTTCCTGACCGAGGAGTTTCCCGACATCGCG
CCCGCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3NJV5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3NE17

References